Evidence map›Paper›PMID 37834409›Full record

ArticleInternational journal of molecular sciences2023

Following Natural Autoantibodies: Further Immunoserological Evidence Regarding Their Silent Plasticity and Engagement in Immune Activation.

David Szinger, Timea Berki, Péter Németh, Szabina Erdo-Bonyar, Diana Simon, Ines Drenjančević, Senka Samardzic, Marija Zelić, Magdalena Sikora, Arlen Požgain and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. COVID-19 Pandemic: Therapeutic Strategies and Vaccines.International journal of molecular sciences · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

David SzingerDepartment of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, 7624 Pécs, Hungary.
Timea BerkiDepartment of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, 7624 Pécs, Hungary.
Péter NémethDepartment of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0002-3406-2010
Szabina Erdo-BonyarDepartment of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, 7624 Pécs, Hungary.
Diana SimonDepartment of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, 7624 Pécs, Hungary.
Ines DrenjančevićDepartment of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.ORCID 0000-0003-4964-7721
Senka SamardzicDepartment of Public Health, Teaching Institute of Public Health for The Osijek-Baranja County, 31000 Osijek, Croatia.
Marija ZelićDepartment of Public Health, Teaching Institute of Public Health for The Osijek-Baranja County, 31000 Osijek, Croatia.
Magdalena SikoraDepartment of Public Health, Teaching Institute of Public Health for The Osijek-Baranja County, 31000 Osijek, Croatia.
Arlen PožgainDepartment of Public Health, Teaching Institute of Public Health for The Osijek-Baranja County, 31000 Osijek, Croatia.
Katalin BöröczDepartment of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0002-6126-1840
University of Pecs · HUInstitute of Public Health Osijek-Baranja County · HRUniversity of Osijek · HR

Funding

National Research, Development and Innovation Fund of Hungary, financed under the TKP-2021-EGA funding scheme TKP-2021-EGA-10 /TKP-2021-EGA-13
6 · The paper itself

Abstract

Contradictory reports are available on vaccine-associated hyperstimulation of the immune system, provoking the formation of pathological autoantibodies. Despite being interconnected within the same network, the role of the quieter, yet important non-pathological and natural autoantibodies (nAAbs) is less defined. We hypothesize that upon a prompt immunological trigger, physiological nAAbs also exhibit a moderate plasticity. We investigated their inducibility through aged and recent antigenic triggers. Anti-viral antibodies (anti-MMR n = 1739 and anti-SARS-CoV-2 IgG n = 330) and nAAbs (anti-citrate synthase IgG, IgM n = 1739) were measured by in-house and commercial ELISAs using Croatian (Osijek) anonymous samples with documented vaccination backgrounds. The results were subsequently compared for statistical evaluation. Interestingly, the IgM isotype nAAb showed a statistically significant connection with anti-MMR IgG seropositivity (

Indexed as

COVID-19VaccinesAgedAntibodies, ViralAutoantibodiesHumansImmunoglobulin GImmunoglobulin MVaccinationAntibodies, ViralAutoantibodiesImmunoglobulin GImmunoglobulin MVaccinesanti-viral antibodyautoantibodyELISAIgGimmunizationimmunological networkMMRnatural autoantibodyplasticitySARS-CoV-2serologyvaccine

Identifiers

PMID37834409
PMCPMC10573785
OpenAlexW4387422867

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.