Evidence map›Paper›PMID 37835232›Full record

ReviewFoods (Basel, Switzerland)2023

Complement in Human Brain Health: Potential of Dietary Food in Relation to Neurodegenerative Diseases.

Yihang Xing, Dingwen Zhang, Li Fang, Ji Wang, Chunlei Liu, Dan Wu, Xiaoting Liu, Xiyan Wang, Weihong Min

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yihang XingCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Dingwen ZhangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Li FangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Ji WangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.ORCID 0000-0002-3603-4670
Chunlei LiuCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Dan WuCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Xiaoting LiuCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Xiyan WangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.ORCID 0000-0002-5062-7077
Weihong MinCollege of Food and Health, Zhejiang A&F University, Hangzhou 311300, China.
Jilin Agricultural University · CNZhejiang A & F University · CN

Funding

Science and Technology Research Project of Jilin Province JJKH20220347KJThe Science and Technology Development Project of Jilin Province 20230202055NC
6 · The paper itself

Abstract

The complement pathway is a major component of the innate immune system, which is critical for recognizing and clearing pathogens that rapidly react to defend the body against external pathogens. Many components of this pathway are expressed throughout the brain and play a beneficial role in synaptic pruning in the developing central nervous system (CNS). However, excessive complement-mediated synaptic pruning in the aging or injured brain may play a contributing role in a wide range of neurodegenerative diseases. Complement Component 1q (C1q), an initiating recognition molecule of the classical complement pathway, can interact with a variety of ligands and perform a range of functions in physiological and pathophysiological conditions of the CNS. This review considers the function and immunomodulatory mechanisms of C1q; the emerging role of C1q on synaptic pruning in developing, aging, or pathological CNS; the relevance of C1q; the complement pathway to neurodegenerative diseases; and, finally, it summarizes the foods with beneficial effects in neurodegenerative diseases via C1q and complement pathway and highlights the need for further research to clarify these roles. This paper aims to provide references for the subsequent study of food functions related to C1q, complement, neurodegenerative diseases, and human health.

Indexed as

C1qcomplement pathwaydietary foodmicroglianeurodegenerative diseasessynaptic pruning

Identifiers

PMID37835232
PMCPMC10572247
OpenAlexW4387105923

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.