Evidence map›Paper›PMID 37835588›Full record

ArticleCancers2023

Human Breast Tissue Microbiota Reveals Unique Microbial Signatures that Correlate with Prognostic Features in Adult Ethiopian Women with Breast Cancer.

Zelalem Desalegn, Alana Smith, Meron Yohannes, Xueyuan Cao, Endale Anberber, Yonas Bekuretsion, Mathewos Assefa, Marcus Bauer, Martina Vetter, Eva Johanna Kantelhardt and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Zelalem DesalegnDepartment of Microbiology, Immunology, and Parasitology, School of Medicine, College of Health Sciences Addis Ababa University, Addis Ababa 9086, Ethiopia.ORCID 0000-0001-9643-8661
Alana SmithDepartment of Genetics, Genomics and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Meron YohannesDepartment of Microbiology, Immunology, and Parasitology, School of Medicine, College of Health Sciences Addis Ababa University, Addis Ababa 9086, Ethiopia.
Xueyuan CaoDepartment of Health Promotion and Disease Prevention, College of Nursing, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-4396-7460
Endale AnberberDepartment of Surgery, School of Medicine, Addis Ababa University, Addis Ababa 9086, Ethiopia.ORCID 0000-0002-0155-2064
Yonas BekuretsionDepartment of Pathology, School of Medicine, Addis Ababa University, Addis Ababa 9086, Ethiopia.
Mathewos AssefaDepartment of Oncology, School of Medicine, Addis Ababa University, Addis Ababa 9086, Ethiopia.
Marcus BauerInstitute of Pathology, Martin Luther University Halle-Wittenberg, 06097 Halle (Saale), Germany.ORCID 0000-0002-0657-6831
Martina VetterDepartment of Gynecology, Martin Luther University Halle-Wittenberg, 06097 Halle (Saale), Germany.ORCID 0000-0002-6642-9585
Eva Johanna KantelhardtGlobal Health Working Group, Martin Luther University Halle-Wittenberg, 06097 Halle (Saale), Germany.ORCID 0000-0001-7935-719X
Tamrat AbebeDepartment of Microbiology, Immunology, and Parasitology, School of Medicine, College of Health Sciences Addis Ababa University, Addis Ababa 9086, Ethiopia.
Athena Starlard-DavenportDepartment of Genetics, Genomics and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-8938-237X
Addis Ababa University · ETMartin Luther University Halle-Wittenberg · DEUniversity of Tennessee Health Science Center · US

Funding

Else-Kroener-Foundation through Martin-Luther-University, Halle-Wittenberg, Germany No. 2018_HA31SPMedical Faculty of the Martin Luther University Halle Wittenberg, Halle (Saale), Germany GTDR16378013
6 · The paper itself

Abstract

Breast cancer (BC) is the leading cause of cancer mortality among women in Ethiopia. Overall, women of African ancestry have the highest death toll due to BC compared to other racial/ethnic groups. The cause of the disparity in mortality is unclear. Recently, studies conducted in the United States and other high-income countries highlighted the role of microbial dysbiosis in BC initiation, tumor growth, and treatment outcome. However, the extent to which inter-individual differences in the makeup of microbiota are associated with clinical and histopathological outcomes in Ethiopian women has not been studied. The goal of our study was to profile the microbiome in breast tumor and normal adjacent to tumor (NAT) tissues of the same donor and to identify associations between microbial composition and abundance and clinicopathological factors in Ethiopian women with BC. We identified 14 microbiota genera in breast tumor tissues that were distinct from NAT tissues, of which

Indexed as

African ancestryBCbreast microbiomeEthiopiamicrobiotaPAM50 molecular intrinsic subtypes

Identifiers

PMID37835588
PMCPMC10571711
OpenAlexW4387460885

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.