Evidence map›Paper›PMID 37835677›Full record

ArticleAnimals : an open access journal from MDPI2023

Genome-Wide Association Study of Maternal Genetic Effects on Intramuscular Fat and Fatty Acid Composition in Rabbits.

Ayman G El Nagar, Imen Heddi, Bolívar Samuel Sosa-Madrid, Agustín Blasco, Pilar Hernández, Noelia Ibáñez-Escriche

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Genome-wide association study of mature cow size traits in American Angus cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ayman G El NagarInstitute for Animal Science and Technology, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-7270-702X
Imen HeddiCentro Regional de Selección y Reproducción Animal (CERSYRA), Av. del Vino, 10, 13300 Valdepeñas, Spain.
Bolívar Samuel Sosa-MadridInstitute for Animal Science and Technology, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-4269-7593
Agustín BlascoInstitute for Animal Science and Technology, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0003-3558-0810
Pilar HernándezInstitute for Animal Science and Technology, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-7857-7334
Noelia Ibáñez-EscricheInstitute for Animal Science and Technology, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-6221-3576
Universitat Politècnica de València · ESBenha University · EGCentro Regional de Selección y Reproducción Animal · ES

Funding

Conselleria for Innovation, Universities, Science and Digital Society of Valencia AICO/2020/349Spanish Ministry of Science and Innovation PID2020-115558GB-C21
6 · The paper itself

Abstract

Maternal genetic effects (MGE) could affect meat quality traits such as intramuscular fat (IMF) and its fatty acid composition. However, it has been scarcely studied, especially in rabbits. The objectives of the present study were, first, to assess the importance of MGE on intramuscular fat and fatty acid composition by applying a Bayesian maternal animal model in two rabbit lines divergently selected for IMF. The second objective was to identify genomic regions and candidate genes of MGE that are associated with the traits of these offspring, using Bayesian methods in a Genome Wide Association Study (GWAS). Quantitative analyses were performed using data from 1982 rabbits, and 349 animals from the 9th generation and 76 dams of the 8th generation with 88,512 SNPs were used for the GWAS. The studied traits were IMF, saturated fatty acids (total SFA, C14:0; myristic acid, C16:0; palmitic acid and C18:0; stearic acid), monounsaturated fatty acids (total MUFA, C16:1n-7; palmitoleic acid and C18:1n-9; oleic acid), polyunsaturated fatty acids (total PUFA, C18:2n-6; linoleic acid, C18:3n-3; α-linolenic acid and C20:4n-6; arachidonic acid), MUFA/SFA and PUFA/SFA. The proportion of phenotypic variance explained by the maternal genetic effect ranged from 8 to 22% for IMF, depending on the model. For fatty acid composition, the proportion of phenotypic variance explained by maternal genetic effects varied from 10% (C18:0) to 46% (MUFA) in a model including both direct and additive maternal genetic effects, together with the common litter effect as a random variable. In particular, there were significant direct maternal genetic correlations for C16:0, C18:1n9, C18:2n6, SFA, MUFA, and PUFA with values ranging from -0.53 to -0.89. Relevant associated genomic regions were located on the rabbit chromosomes (OCU) OCU1, OCU5 and OCU19 containing some relevant candidates (

Indexed as

divergent selectionfatty acidsGWASintramuscular fatmaternal genetic effectsrabbits

Identifiers

PMID37835677
PMCPMC10571580
OpenAlexW4387259153

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.