Evidence map›Paper›PMID 37841839›Full record

ArticleResearch square2023

Genetic overlap between Alzheimer's disease and immune-mediated diseases: An atlas of shared genetic determinants and biological convergence.

Brisa Fernandes, Nitesh Enduru, Brisa Fernandes, Shahram Bahrami, Yulin Dai, Ole Andreassen, Zhongming Zhao

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Brisa FernandesUniversity of Texas Health Center at Houston.ORCID 0000-0002-3797-7582
Nitesh EnduruORCID 0000-0002-0255-706X
Brisa FernandesUniversity of Texas Health Center at Houston.
Shahram BahramiThe University of Texas Health Science Center at Houston.
Yulin DaiThe University of Texas Health Science Center at Houston.ORCID 0000-0003-1874-7893
Ole AndreassenOslo University Hospital & Institute of Clinical Medicine, University of Oslo.ORCID 0000-0002-4461-3568
Zhongming ZhaoThe University of Texas Health Science Center at Houston.ORCID 0000-0002-3477-0914
The University of Texas Health Science Center at Houston · USOslo University Hospital · NO

Funding

AIM-AI: an Actionable, Integrated and Multiscale genetic map of Alzheimer's disease via deep learningU01AG079847 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Christopher A. Gaiteri, Xiaoqian Jiang · 2023 to 2026
$5.1M
Transforming dbGaP genetic and genomic data to FAIR-ready by artificial intelligence and machine learning algorithmsR01LM012806 · NLM · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhongming Zhao · 2017 to 2026
$3.7M
Constructing A Transcriptomic Atlas of Retrotransposon in Alzheimer's DiseaseR03AG077191 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHAO, ZHONGMING · 2022 to 2022
$312k
NIA NIH HHS R03 AG077191NIA NIH HHS U01 AG079847NLM NIH HHS R01 LM012806
6 · The paper itself

Abstract

The occurrence of immune disease comorbidities in Alzheimer's disease (AD) has been observed in both epidemiological and molecular studies, suggesting a neuroinflammatory basis in AD. However, their shared genetic components have not been systematically studied. Here, we composed an atlas of the shared genetic associations between 11 immune-mediated diseases and AD by analyzing genome-wide association studies (GWAS) summary statistics. Our results unveiled a significant genetic overlap between AD and 11 individual immune-mediated diseases despite negligible genetic correlations, suggesting a complex shared genetic architecture distributed across the genome. The shared loci between AD and immune-mediated diseases implicated several genes, including

Indexed as

Alzheimer’s diseasegenetic correlationgenome-wide association studiesimmune-mediated diseasesMendelian randomizationpleiotropy

Identifiers

PMID37841839
PMCPMC10571609
OpenAlexW4387131048

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.