ArticleResearch square2023
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids.
Yang Yang, Jiaxiang Wu, Jingliang Zhang, Xiaoling Chen, Zhefu Que, Kyle Wettschurack, Brody Deming, Maria Acosta, Ningren Cui, Muriel Eaton and 13 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 13 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
23 authors at 1 institution in 1 country.
Yang YangPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Jiaxiang WuPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Jingliang ZhangPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Xiaoling ChenPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Zhefu QuePurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Kyle WettschurackPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Brody DemingPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Maria AcostaPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Ningren CuiPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Muriel EatonPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Yuanrui ZhaoPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Manasi HalurkarPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Mandal PurbaPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Ian ChenPurdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN).
Tiange Xiao
Matthew Suzuki
Chongli Yuan
Ranjie Xu
Wendy Koss
Dongshu Du
Fuxue Chen
Long-Jun Wu
WinnMed · US
Funding
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2MNeuronal and Behavioral Deficits Associated with Scn2a Deficiency in Autism Spectrum DisorderR01NS117585 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$2.0MNeuronal hyperexcitability and seizures in a Scn2a deficient mouse modelR01NS123154 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$1.9MNCATS NIH HHS UL1 TR002529NINDS NIH HHS R01 NS117585NINDS NIH HHS R01 NS123154
6 · The paper itselfAbstract
Autism spectrum disorder (ASD) is a major neurodevelopmental disorder affecting 1 in 36 children in the United States. While neurons have been the focus to understand ASD, an altered neuro-immune response in the brain may be closely associated with ASD, and a neuro-immune interaction could play a role in the disease progression. As the resident immune cells of the brain, microglia regulate brain development and homeostasis via core functions including phagocytosis of synapses. While ASD has been traditionally considered a polygenic disorder, recent large-scale human genetic studies have identified
Indexed as
DevelopmentMicrogliaOrganoidsSCN2ASynaptic pruning
Identifiers
PMID37841865
PMCPMC10571631
OpenAlexW4387131080
What Socratic holds
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LicenceCC BY
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