Evidence map›Paper›PMID 37842778›Full record

ArticleDevelopment (Cambridge, England)2023

HEXOKINASE1 and glucose-6-phosphate fuel plant growth and development.

Morgan Vanderwall, Joshua M Gendron

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  4. Hybrids reveal accessible chromatinbioRxiv : the preprint server for biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Morgan VanderwallDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.ORCID 0000-0001-8875-7996
Joshua M GendronDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.ORCID 0000-0001-8605-3047
Yale University · US

Funding

Protein degradation mechanisms that regulate daily and seasonal timingR35GM128670 · NIGMS · YALE UNIVERSITY · PI Joshua Martin Gendron · 2018 to 2026
$4.0M
NIGMS NIH HHS R35 GM128670
6 · The paper itself

Abstract

As photoautotrophic organisms, plants produce an incredible spectrum of pigments, anti-herbivory compounds, structural materials and energic intermediates. These biosynthetic routes help plants grow, reproduce and mitigate stress. HEXOKINASE1 (HXK1), a metabolic enzyme and glucose sensor, catalyzes the phosphorylation of hexoses, a key introductory step for many of these pathways. However, previous studies have largely focused on the glucose sensing and signaling functions of HXK1, and the importance of the enzyme's catalytic function is only recently being connected to plant development. In this brief Spotlight, we describe the developmental significance of plant HXK1 and its role in plant metabolic pathways, specifically in glucose-6-phosphate production. Furthermore, we describe the emerging connections between metabolism and development and suggest that HXK1 signaling and catalytic activity regulate discrete areas of plant development.

Indexed as

Glucose-6-PhosphateHexokinasePlant DevelopmentGlucosePhosphorylationPlantsGlucoseGlucose-6-PhosphateHexokinaseGlucose phosphorylationGlucose signalingGlycolysisHXK1Leaf senescenceSugar sensing

Identifiers

PMID37842778
PMCPMC10617624
OpenAlexW4387661465

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.