A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression.

Amrit Sudershan, Agar Chander Pushap, Hardeep Kumar, Parvinder Kumar

Abstract readMeta-Analysis

In one paragraph

Synthesis in Journal of molecular neuroscience : MN, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

2.0field-weighted citation impact, top 14% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

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Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Amrit SudershanInstitute of Human Genetics, University of Jammu, Jammu and Kashmir 180006, Gujarbasti, Jammu, India.

Agar Chander PushapDepartment of Education, Dakshina Bharat Hindi Prachar Sabha, Madras, 600017, India.

Hardeep KumarDepartment of Neurology, Super Specialty Hospital, Jammu and Kashmir 180006, Jammu, India.

Parvinder KumarInstitute of Human Genetics, University of Jammu, Jammu and Kashmir 180006, Gujarbasti, Jammu, India. drparvinderkumar@jammuuniversity.ac.in.ORCID http://orcid.org/0000-0003-1039-6638

Dakshina Bharat Hindi Prachar Sabha · INJammu Hospital · INUniversity of Jammu · INUniversity of Kashmir · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many homeostatic genes are thought to play a role in the susceptibility to migraine, making it a highly complex neurovascular disease. In this meta-analysis, our primary objective was to evaluate whether or not MTHFR variants (such as C677T and A1289C) and ACE I/D were associated with an increased risk of migraine. Using a PRISMA-based systematic literature-review guideline, internet sources such as PubMed and Google Scholar were searched to identify the genes of interest and migraine risk. To pool the data, odds ratios with 95% confidence intervals were calculated utilizing different genetic models. Cochran's Q Test and I

Indexed as

Genetic Predisposition to DiseaseMigraine DisordersAllelesGenetic Association StudiesHumansMethylenetetrahydrofolate Reductase (NADPH2)Peptidyl-Dipeptidase APolymorphism, Single NucleotideRisk FactorsACE protein, humanMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanPeptidyl-Dipeptidase AA1289CACEACE I/DC677TMigraineMTHFR

Identifiers

PMID37843720

DOI10.1007/s12031-023-02164-5

OpenAlexW4387661393

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.