Evidence map›Paper›PMID 37844279›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2023

The Transplant Bellwether: Endothelial Cells in Antibody-Mediated Rejection.

Adriana Franco-Acevedo, Christopher L Pathoulas, Patrick A Murphy, Nicole M Valenzuela

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Immunosuppression Management in Heart Transplantation.Methodist DeBakey cardiovascular journal · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Adriana Franco-AcevedoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0003-4402-9967
Christopher L PathoulasCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT.
Patrick A MurphyCenter for Vascular Biology, University of Connecticut Medical School, Farmington, CT.
Nicole M ValenzuelaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0003-2024-5382
University of California, Los Angeles · USUniversity of Connecticut · US

Funding

Targeting Inflammation and Alloimmunity in Lung Transplant Recipients With ClazakizumabU01AI163086 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Ramsey Hachem, Daniel Kreisel · 2021 to 2026
$15.5M
Targeting Inflammation and Alloimmunity in Heart Transplant Recipients with TocilizumabU01AI136816 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2018 to 2023
$12.9M
The role of HLA and its coreceptors in endothelial cell activation and leukocyte recruitment in antibody-mediated transplant rejectionR01AI135201 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert L Fairchild, ELAINE F REED · 2018 to 2026
$5.3M
RNA-Binding Proteins in the Regulation of Vascular Inflammation and ImmunityR01HL150362 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MURPHY, PATRICK ANDRIES · 2021 to 2025
$2.7M
The UConn/JAX-GM Training Program in Genomic ScienceT32HG010463 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Mark D ADAMS, Christine R Beck · 2020 to 2026
$1.5M
NHGRI NIH HHS T32 HG010463NHLBI NIH HHS R01 HL150362NIAID NIH HHS R01 AI135201NIAID NIH HHS U01 AI136816NIAID NIH HHS U01 AI163086
6 · The paper itself

Abstract

Ab-mediated rejection of organ transplants remains a stubborn, frequent problem affecting patient quality of life, graft function, and grant survival, and for which few efficacious therapies currently exist. Although the field has gained considerable knowledge over the last two decades on how anti-HLA Abs cause acute tissue injury and promote inflammation, there has been a gap in linking these effects with the chronic inflammation, vascular remodeling, and persistent alloimmunity that leads to deterioration of graft function over the long term. This review will discuss new data emerging over the last 5 y that provide clues into how ongoing Ab-endothelial cell interactions may shape vascular fate and propagate alloimmunity in organ transplants.

Indexed as

Endothelial CellsQuality of LifeAntibodiesGraft RejectionHLA AntigensHumansInflammationAntibodiesHLA Antigens

Identifiers

PMID37844279
PMCPMC10593495
OpenAlexW4387686199

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.