Evidence map›Paper›PMID 37844994›Full record

ArticleJournal for immunotherapy of cancer2023

C-reactive protein impairs immune response of CD8

Jinxing Jiang, Ziyi Peng, Junying Wang, Mengping Chen, Yike Wan, Honghui Huang, Zhiqiang Liu, Jingya Wang, Jian Hou

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  5. Hemocyanin controlsVirulence · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jinxing Jiang *Department of Hematology, Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-2109-4822
Ziyi Peng *Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China jingyawang@tmu.edu.cn
Junying Wang *Department of Hematology, Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mengping ChenDepartment of Hematology, Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yike WanDepartment of Hematology, Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Honghui HuangDepartment of Hematology, Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhiqiang LiuDepartment of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China jingyawang@tmu.edu.cnORCID 0000-0002-0677-8097
Jingya WangDepartment of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China jingyawang@tmu.edu.cn
Jian HouDepartment of Hematology, Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China houjian@medmail.com.cn.
Shanghai Jiao Tong University · CNTianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundC-reactive protein (CRP) is a prototypical acute phase protein in humans with the function of regulating immune cells. Serum CRP levels are elevated in multiple myeloma (MM), associated with MM cell proliferation and bone destruction. However, its direct effects on T lymphocytes in MM have not been elucidated.

methodsPublic data sets were used to explore the correlation of CRP levels with immune cell infiltration and cytotoxicity score of CD8

resultsCRP levels were negatively correlated with cell-infiltration and cytotoxicity score of CD8

conclusionsWe found that CRP impaired immune response of CD8

Indexed as

CD8-Positive T-LymphocytesMultiple MyelomaAnimalsB-Cell Maturation AntigenC-Reactive ProteinHumansImmunityMiceMice, Inbred C57BLp38 Mitogen-Activated Protein KinasesReactive Oxygen SpeciesB-Cell Maturation AntigenC-Reactive Proteinp38 Mitogen-Activated Protein KinasesReactive Oxygen SpeciesAdaptive ImmunityBiomarkers, TumorCD8-Positive T-LymphocytesImmunologic Surveillance

Identifiers

PMID37844994
PMCPMC10582887
OpenAlexW4387675888

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.