ArticleMolecular pain
The pace of biological aging helps explain the association between insomnia and chronic low back pain.
Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 16 citations in OpenAlex.
- Epigenetic Regulation of Modulatory Neurotransmitter System Integrity in the Aging Brain: A Scoping Review Across the Lifespan.Life (Basel, Switzerland) · 2026Review
- Association of the waist-to-weight index with low back pain: a mediation analysis involving accelerated biological ageing.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Association of nighttime sleep duration and quality with low back pain in middle-aged and elderly Chinese: a nationwide longitudinal cohort study.BMC public health · 2026Article
- Biomarkers and Breakdowns: Neuroinflammatory Drivers Linking Sleep Disorders and Chronic Pain.Biomedicines · 2026Review
- Acupuncture Therapy Combined with Core Stability Training for Chronic Nonspecific Low Back Pain: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.Journal of pain research · 2026Review
- Serial Mediation: How Optimism Reduces and Pessimism Intensifies Chronic Low Back Pain Through Depression and Biological Aging.Biological research for nursing · 2026Article
- Effectiveness of acupressure at different ear acupoints on Insomnia: A secondary analysis of a randomized controlled trial.Sleep medicine: X · 2025Article
- EpInflammAge: Epigenetic-Inflammatory Clock for Disease-Associated Biological Aging Based on Deep Learning.International journal of molecular sciences · 2025Article
- Article
- Sleep characteristics and intervertebral disc degeneration risk: an observational and Mendelian randomization study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Observational
- Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study.Clinical epigenetics · 2025Article
- Modifiable risk factors that mediate the effect of insomnia on the risk of low back pain: a network mendelian randomization study.Hereditas · 2024Article
- The association between sleep disorder, sleep duration and chronic back pain: results from National Health and Nutrition Examination Surveys, 2009-2010.BMC public health · 2024Article
- High-Impact Pain Is Associated With Epigenetic Aging Among Middle-Aged and Older Adults: Findings From the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- The Pace of Biological Aging Partially Explains the Relationship Between Socioeconomic Status and Chronic Low Back Pain Outcomes.Journal of pain research · 2024Article
- The Combined Effect Between Sleep Disorders and Depression Symptoms on Chronic Low Back Pain: A Cross-Sectional Study of NHANES.Journal of pain research · 2024Article
- The pace of biological aging significantly mediates the relationship between internalized stigma of chronic pain and chronic low back pain severity among non-hispanic black but not non-hispanic white adults.Neurobiology of pain (Cambridge, Mass.)Article
- Beyond restless sleep: A cross-sectional study of obstructive sleep apnea risk, aging biomarkers, and chronic low back pain.Molecular painArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic low back pain (cLBP) is associated with insomnia and advanced age. Emerging evidence suggests that the severity of both sleep disorders (like insomnia) and chronic pain are associated with a faster pace of biological aging. We aimed to determine whether the pace of biological age mediates the relationship between insomnia and the impact of cLBP in a sample of community-dwelling adults ages 19 to 85 years. Participants (49 with no pain, 32 with low-impact pain, and 37 with high-impact pain) completed sociodemographic, pain, insomnia, and short physical performance battery assessments. We calculated the pace of biological aging using DunedinPACE from blood leukocyte DNA. On average, individuals with high-impact cLBP had significantly faster biological aging than those with low-impact and no chronic pain (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.