Evidence map›Paper›PMID 37845116›Full record

ReviewThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2024

Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research.

Breno S Diniz, Johanna Seitz-Holland, Raghav Sehgal, Jessica Kasamoto, Albert T Higgins-Chen, Eric Lenze

Open access · bronzeAbstract readReview
In one paragraph

Review in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Moderators of treatment response in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  2. The spectrum of bipolar disorder in older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  3. Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Breno S DinizUConn Center on Aging & Department of Psychiatry (BSD), School of Medicine, University of Connecticut Health Center, Farmington, CT. Electronic address: diniz@uchc.edu.
Johanna Seitz-HollandDepartment of Psychiatry (JSH), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry (JSH), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Raghav SehgalProgram in Computational Biology and Bioinformatics (RS, JK), Yale University, New Haven, CT.
Jessica KasamotoProgram in Computational Biology and Bioinformatics (RS, JK), Yale University, New Haven, CT.
Albert T Higgins-ChenDepartment of Psychiatry (ATHC), Yale University School of Medicine, New Haven, CT; Department of Pathology (ATHC), Yale University School of Medicine, New Haven, CT.
Eric LenzeDepartment of Psychiatry (EL), School of Medicine, Washington University at St. Louis, St. Louis, MO.
Yale University · USBrigham and Women's Hospital · USUConn Health · USWashington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
MEDICAL INFORMATICS RESEARCH TRAINING AT YALET15LM007056 · NLM · YALE UNIVERSITY · PI Mark Bender Gerstein, LUCILA OHNO-MACHADO · 1987 to 2026
$22.2M
Resilience and brain health of older adults during the COVID-19 pandemicR01AG072694 · NIA · WASHINGTON UNIVERSITY · PI DINIZ, BRENO SATLER, LENZE, ERIC J · 2021 to 2025
$9.1M
Molecular Networks Underlying Resilience to Alzheimer's Disease Among APOE E4 CarriersR01AG057912 · NIA · YALE UNIVERSITY · PI GAITERI, CHRISTOPHER A., HIGGINS-CHEN, ALBERT TZONGYANG · 2017 to 2021
$4.5M
QUANTITATIVE ASSESSMENT OF BIOLOGICAL AGE AND ITS APPLICATIONSR01AG065403 · NIA · YALE UNIVERSITY · PI Vadim N. Gladyshev, Albert Tzongyang Higgins-Chen · 2020 to 2026
$4.2M
THE SENDEP STUDY: LINKING MOLECULAR SENESCENCE CHANGES TO DEPRESSION AND COGNITIVE IMPAIRMENT IN LATE LIFER01MH115953 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DINIZ, BRENO SATLER · 2019 to 2023
$3.0M
Social Circumstances and Epigenomics Promoting Health in Three CountriesR01AG068937 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIMMINS, EILEEN M, FAUL, JESSICA · 2020 to 2025
$2.9M
EVALUATION OF MOLECULAR MECHANISMS OF TREATMENT RESPONSE IN LATE LIFE DEPRESSIONR01MH118311 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DINIZ, BRENO SATLER, TSENG, GEORGE C. · 2019 to 2022
$2.0M
NCATS NIH HHS UL1 TR002345NIA NIH HHS R01 AG057912NIA NIH HHS R01 AG065403NIA NIH HHS R01 AG068937NIA NIH HHS R01 AG072694NIMH NIH HHS R01 MH115953NIMH NIH HHS R01 MH118311NLM NIH HHS T15 LM007056
6 · The paper itself

Abstract

The geroscience hypothesis asserts that physiological aging is caused by a small number of biological pathways. Despite the explosion of geroscience research over the past couple of decades, the research on how serious mental illnesses (SMI) affects the biological aging processes is still in its infancy. In this review, we aim to provide a critical appraisal of the emerging literature focusing on how we measure biological aging systematically, and in the brain and how SMIs affect biological aging measures in older adults. We will also review recent developments in the field of cellular senescence and potential targets for interventions for SMIs in older adults, based on the geroscience hypothesis.

Indexed as

GeroscienceMental HealthAgedAgingBiologyGeriatric PsychiatryHumansAginggerosciencelate-life depressionserious mental illnesses

Identifiers

PMID37845116
PMCPMC10841054
OpenAlexW4386983225

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.