Evidence mapPaperPMID 37846408Full record

ArticleAdvances in drug and alcohol research2023

Alcohol and pregnenolone interaction on cerebral arteries through targeting of vascular smooth muscle

Kelsey C North, Andrew A Shaw, Luiz Moreira, Anna N Bukiya, Alex M Dopico

Open access · diamondAbstract read
In one paragraph

Article in Advances in drug and alcohol research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kelsey C NorthDepartment Pharmacology, Addiction Science and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, United States.
Andrew A ShawDepartment Pharmacology, Addiction Science and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, United States.
Luiz MoreiraDepartment Pharmacology, Addiction Science and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, United States.
Anna N BukiyaDepartment Pharmacology, Addiction Science and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, United States.
Alex M DopicoDepartment Pharmacology, Addiction Science and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, United States.
University of Tennessee Health Science Center · US

Funding

ETHANOL ACTIONS ON SLO CHANNELS FROM ARTERIES VS BRAINR01AA011560 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Alex Dopico · 2001 to 2026
$4.4M
Regulation of arterial diameter through specific sensing of endogenous steroids and novel nonsteroidal analogs by BK channel subunitsR01HL147315 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DOPICO, ALEX M. · 2019 to 2022
$2.4M
Pregnenolone constricts cerebral vascular arteries through the direct modulation of BK ion channelsF31HL156290 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI NORTH, KELSEY CLELAND · 2021 to 2022
$67k
NHLBI NIH HHS F31 HL156290NHLBI NIH HHS R01 HL147315NIAAA NIH HHS R01 AA011560
6 · The paper itself

Abstract

Despite the significant number of people who may be taking pregnenolone supplements while drinking alcohol (ethanol), the widely documented cerebrovascular actions of pregnenolone and ethanol, and the critical dependence of cerebrovascular function on cerebral artery diameter, there are no studies addressing the effect of pregnenolone + ethanol in combination on cerebral artery diameter. We investigated this by evaluating the effect of this combination on middle cerebral artery diameter in male and female C57BL/6J mice, both

Indexed as

alcohol intoxicationcerebral arteriesMaxiK channelneurosteroidsvascular smooth muscle

Identifiers

PMID37846408
PMCPMC10578043
OpenAlexW4385808095

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.