Evidence map›Paper›PMID 37846600›Full record

ArticleJournal of diabetes2024

Washed microbiota transplantation reduces glycemic variability in unstable diabetes.

Yangyang Li, Qing Liu, Lingyu Zhang, Jing Zou, Rongbo He, Ying Zhou, Chen Qian, Yuxiao Zhu, Rourou Chen, Ying Zhang and 8 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06340217 (The Efficacy and Safety of WMT in the Treatment of Diabetic Gastroparesis), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06340217 narecruitingnot on this map

The Efficacy and Safety of WMT in the Treatment of Diabetic Gastroparesis: A Multicenter, Randomized, Double-blind, Placebo-controlled Study

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2024 to 2029Enrolled46ConditionsDiabetic GastroparesisArmswashed microbiota transplantation, placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Yangyang LiDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Qing LiuDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Lingyu ZhangDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Jing ZouDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Rongbo HeDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Ying ZhouDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Chen QianDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Yuxiao ZhuDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Rourou ChenDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Ying ZhangDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Pengpeng CaiDigestive Endoscopy Center, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Miao WangDivision of Microbiotherapy, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Wei ShaoDepartment of Science and Technology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Minjun JiDepartment of Pathogen Biology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, China.
Hao WuHuman Phenome Institute, Fudan University, Shanghai, China.
Faming ZhangDivision of Microbiotherapy, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Zejian LiuKey Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China.
Yu LiuDepartment of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0001-6012-5305
Nanjing Medical University · CNFudan University · CNNanjing University of Science and Technology · CNSecond Affiliated Hospital of Nanjing Medical University · CN

Funding

National Key R&D Program of China 2022YFA0806103National Natural Science Foundation of China 81770778National Natural Science Foundation of China 81800724National Natural Science Foundation of China 81800735National Natural Science Foundation of China 82070849National Natural Science Foundation of China 82270871Natural Science Foundation of Jiangsu Province BK20180672Natural Science Foundation of the Jiangsu Higher Education Institutions 18KJB310005the Jiangsu Provincial Key Research Development Program BE2022794
6 · The paper itself

Abstract

backgroundDysbiosis of gut microbiota is causally linked to impaired host glucose metabolism. We aimed to study effects of the new method of fecal microbiota transplantation, washed microbiota transplantation (WMT), on reducing glycemic variability (GV) in unstable diabetes.

methodsFourteen eligible patients received three allogenic WMTs and were followed up at 1 week, 1 month, and 3 months. Primary outcomes were daily insulin dose, glucose excursions during meal tests, and GV indices calculated from continuous monitoring or self-monitoring glucose values. Secondary outcomes were multiomics data, including 16S rRNA gene sequencing, metagenomics, and metabolomics to explore underlying mechanisms.

resultsDaily insulin dose and glucose excursions markedly dropped, whereas GV indices significantly improved up to 1 month. WMT increased gut microbial alpha diversity, beta diversity, and network complexity. Taxonomic changes featured lower abundance of genera Bacteroides and Escherichia-Shigella, and higher abundance of genus Prevotella. Metagenomics functional annotations revealed enrichment of distinct microbial metabolic pathways, including methane biosynthesis, citrate cycle, amino acid degradation, and butyrate production. Derived metabolites correlated significantly with improved GV indices. WMT did not change circulating inflammatory cytokines, enteroendocrine hormones, or C-peptide.

conclusionsWMT showed strong ameliorating effect on GV, raising the possibility of targeting gut microbiota as an effective regimen to reduce GV in diabetes.

Indexed as

Diabetes MellitusGastrointestinal MicrobiomeGlucoseHumansInsulinRNA, Ribosomal, 16SGlucoseInsulinRNA, Ribosomal, 16Sfecal microbiota transplantationglycemic variabilityhypoglycemiamicrobiomeunstable diabetes

Identifiers

PMID37846600
PMCPMC10859319
OpenAlexW4387692154

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.