Evidence map›Paper›PMID 37846984›Full record

ArticleJournal of virology2023

Heterologous prime-boost immunization induces protection against dengue virus infection in cynomolgus macaques.

Poonsook Keelapang, Chutitorn Ketloy, Chunya Puttikhunt, Rungtawan Sriburi, Eakachai Prompetchara, Malinee Sae-Lim, Bunpote Siridechadilok, Thaneeya Duangchinda, Sansanee Noisakran, Nicha Charoensri and 14 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 2 countries.

Poonsook Keelapang *Department of Microbiology, Faculty of Medicine, Chiang Mai University , Chiang Mai, Thailand.ORCID 0000-0003-2036-4437
Chutitorn Ketloy *Center of Excellence in Vaccine Research and Development, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand.
Chunya PuttikhuntMolecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency , Pathumthani, Thailand.
Rungtawan SriburiDepartment of Microbiology, Faculty of Medicine, Chiang Mai University , Chiang Mai, Thailand.ORCID 0000-0002-8900-9233
Eakachai PrompetcharaCenter of Excellence in Vaccine Research and Development, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand.
Malinee Sae-LimDepartment of Microbiology, Faculty of Medicine, Chiang Mai University , Chiang Mai, Thailand.
Bunpote SiridechadilokDivision of Dengue Hemorrhagic Fever Research, Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok, Thailand.
Thaneeya DuangchindaMolecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency , Pathumthani, Thailand.
Sansanee NoisakranMolecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency , Pathumthani, Thailand.
Nicha CharoensriCenter for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University , Khon Kaen, Thailand.
Prapat SuriyapholSiriraj Informatics and Data Innovation Center, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok, Thailand.
Piyanan SuparattanagoolClinical Epidemiology Unit, Faculty of Medicine, Khon Kaen University , Khon Kaen, Thailand.
Utaiwan UtaipatResearch Institute for Health Sciences, Chiang Mai University , Chiang Mai, Thailand.
Promsin MasrinoulCenter for Vaccine Development, Institute of Molecular Biosciences, Mahidol University at Salaya , Nakhon Pathom, Thailand.
Panisadee AvirutnanMolecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency , Pathumthani, Thailand.
Juthathip MongkolsapayaDivision of Dengue Hemorrhagic Fever Research, Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok, Thailand.
Gavin ScreatonWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford , Oxford, United Kingdom.
Prasert AuewarakulDepartment of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok, Thailand.
Suchinda MalaivijitnondNational Primate Research Center of Thailand, Chulalongkorn University , Bangkok, Thailand.
Sutee YoksanCenter for Vaccine Development, Institute of Molecular Biosciences, Mahidol University at Salaya , Nakhon Pathom, Thailand.
Prida MalasitMolecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency , Pathumthani, Thailand.
Kiat RuxrungthamCenter of Excellence in Vaccine Research and Development, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand.ORCID 0000-0001-7348-2352
Rojjanaporn PulmanausahakulPrincess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy , Bangkok, Thailand.ORCID 0000-0002-5637-068X
Nopporn SittisombutDepartment of Microbiology, Faculty of Medicine, Chiang Mai University , Chiang Mai, Thailand.ORCID 0000-0003-4678-8721
Chiang Mai University · THNational Science and Technology Development Agency · THChulalongkorn University · THSiriraj Hospital · THKhon Kaen University · THMahidol University · THCentre for Human Genetics · GBChulabhorn Hospital · TH

Funding

Wellcome Trust 203224/Z/16/Z
6 · The paper itself

Abstract

importanceCurrently licensed dengue vaccines do not induce long-term protection in children without previous exposure to dengue viruses in nature. These vaccines are based on selected attenuated strains of the four dengue serotypes and employed in combination for two or three consecutive doses. In our search for a better dengue vaccine candidate, live attenuated strains were followed by non-infectious virus-like particles or the plasmids that generate these particles upon injection into the body. This heterologous prime-boost immunization induced elevated levels of virus-specific antibodies and helped to prevent dengue virus infection in a high proportion of vaccinated macaques. In macaques that remained susceptible to dengue virus, distinct mechanisms were found to account for the immunization failures, providing a better understanding of vaccine actions. Additional studies in humans in the future may help to establish whether this combination approach represents a more effective means of preventing dengue by vaccination.

Indexed as

DengueDengue VaccinesDengue VirusVaccines, Virus-Like ParticleAnimalsAntibodies, ViralHumansImmunization, SecondaryMacaca fascicularisAntibodies, ViralDengue VaccinesVaccines, Virus-Like Particleattenuated virusdengueDNA vaccineprime-boost immunizationvirus-like particle

Identifiers

PMID37846984
PMCPMC10688363
OpenAlexW4387692076

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.