ArticleDevelopment (Cambridge, England)2023
Insulin signaling in development.
Article in Development (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Characterization and cellularity of myofibers during early development of Magalobrama amblycephala.Fish physiology and biochemistry · 2026Article
- A single-cell atlas of alternative wing development in two hemipteran species.Nature communications · 2026Article
- Heterokairic Genes and the Eco-Evo-Devo of Timing.Evolution & development · 2026Review
- INS-17 acts as a nutrient deprivation signal to mediate adult IIS-regulated associative behaviors in C. elegans.PLoS genetics · 2026Article
- Insulin-like peptides play distinct roles in nutrient-dependent plasticity in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Maternal lipids prime quiescent neural stem cells to reactivate in response to dietary nutrients.bioRxiv : the preprint server for biology · 2026Article
- Elevated triglyceride glucose-body mass index is associated with a higher risk of reduced cumulative live birth and adverse pregnancy outcomes in women undergoing assisted reproductive technology: a retrospective cohort study.Frontiers in endocrinology · 2026Observational
- Using Whole-Genome Sequencing Data Reveals the Population Structure and Selection Signatures for Reproduction Traits in Duolang Sheep.Animals : an open access journal from MDPI · 2025Article
- INS-17, an insulin-receptor ligand, confers specificity in adult IIS-regulated phenotypes inbioRxiv : the preprint server for biology · 2025Article
- Genomic and insulin-mediated control of metabolic homeostasis by the mosquito ecdysone-induced gene E93.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The insulin signalling network.Nature metabolism · 2025Review
- Overload of Glucose Metabolism as Initiating Factor in Diabetic Embryopathy and Prevention by Glyoxalase 1 Inducer Dietary Supplement.Antioxidants (Basel, Switzerland) · 2025Article
- Regulation and function of insulin and insulin-like growth factor receptor signalling.Nature reviews. Molecular cell biology · 2025Review
- Natural Bioactive Compounds in Sheep Milk: Potential Biomedical Applications.Current issues in molecular biology · 2025Review
- Article
- Role of beta-hydroxybutyrate measurement in the evaluation of plasma glucose concentrations in newborn infants.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Insulin Signaling Pathway Mediates FoxO-Pepck Axis Regulation of Glucose Homeostasis inInternational journal of molecular sciences · 2024Article
- Association between dietary soy prevention of fetal alcohol spectrum disorder and normalization of placental insulin and insulin-like growth factor signaling networks and downstream effector molecule expression.Gene & protein in disease · 2024Article
- Why Do We Study Aquatic Organisms?International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nutrient intake is obligatory for animal growth and development, but nutrients alone are not sufficient. Indeed, insulin and homologous hormones are required for normal growth even in the presence of nutrients. These hormones communicate nutrient status between organs, allowing animals to coordinate growth and metabolism with nutrient supply. Insulin and related hormones, such as insulin-like growth factors and insulin-like peptides, play important roles in development and metabolism, with defects in insulin production and signaling leading to hyperglycemia and diabetes. Here, we describe the insulin hormone family and the signal transduction pathways activated by these hormones. We highlight the roles of insulin signaling in coordinating maternal and fetal metabolism and growth during pregnancy, and we describe how secretion of insulin is regulated at different life stages. Additionally, we discuss the roles of insulin signaling in cell growth, stem cell proliferation and cell differentiation. We provide examples of the role of insulin in development across multiple model organisms: Caenorhabditis elegans, Drosophila, zebrafish, mouse and human.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.