Evidence map›Paper›PMID 37847229›Full record

ArticleEuropean journal of neurology2024

Progression of brain cholinergic dysfunction in patients with isolated rapid eye movement sleep behavior disorder.

Kristian Staer, Alex Iranzo, Miriam Højholt Terkelsen, Morten Gersel Stokholm, Erik Hvid Danielsen, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B Svendsen, Alicia Garrido and 8 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Kristian StaerDepartment of Nuclear Medicine & PET, Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark.ORCID 0000-0001-8202-242X
Alex IranzoDepartment of Neurology, Hospital Clínic de Barcelona, Barcelona, Spain.ORCID 0000-0002-5618-8271
Miriam Højholt TerkelsenDepartment of Nuclear Medicine & PET, Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark.ORCID 0000-0003-0971-3747
Morten Gersel StokholmDepartment of Nuclear Medicine & PET, Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Erik Hvid DanielsenDepartment of Neurology, Aarhus University Hospital, Aarhus N, Denmark.
Karen ØstergaardDepartment of Neurology, Aarhus University Hospital, Aarhus N, Denmark.
Mónica SerradellDepartment of Neurology, Hospital Clínic de Barcelona, Barcelona, Spain.
Marit OttoDepartment of Neurology, Aarhus University Hospital, Aarhus N, Denmark.
Kristina B SvendsenDepartment of Neurology, Aarhus University Hospital, Aarhus N, Denmark.
Alicia GarridoCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Catalonia, Spain.
Dolores VilasCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Catalonia, Spain.
Joan SantamariaDepartment of Neurology, Hospital Clínic de Barcelona, Barcelona, Spain.
Arne MøllerDepartment of Nuclear Medicine & PET, Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Carles GaigDepartment of Neurology, Hospital Clínic de Barcelona, Barcelona, Spain.
David J BrooksDepartment of Nuclear Medicine & PET, Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Per BorghammerDepartment of Nuclear Medicine & PET, Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Eduardo TolosaCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Catalonia, Spain.
Nicola PaveseDepartment of Nuclear Medicine & PET, Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Aarhus University · DKBiomedical Research Networking Center on Neurodegenerative Diseases · ESAarhus University Hospital · DKHospital Clínic de Barcelona · ES

Funding

Danish Parkinson's AssociationDanmarks Frie ForskningsfondInstituto de Salud Carlos III
6 · The paper itself

Abstract

backgroundReduced cortical acetylcholinesterase activity, as measured by

methodsTwelve iRBD patients underwent

resultsFrom baseline to follow-up, the mean

conclusionsOur results show that severity of brain cholinergic dysfunction in iRBD patients increases significantly over 3 years, and those changes are more severe in those with a decline in cognitive test scores.

Indexed as

Parkinson DiseaseREM Sleep Behavior DisorderAcetylcholinesteraseBrainDonepezilHumansAcetylcholinesteraseDonepezilbiomarkerscognitionParkinson's diseasepositron emission tomographyREM sleep behavior disorder

Identifiers

PMID37847229
PMCPMC11236023
OpenAlexW4387692396

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.