Evidence map›Paper›PMID 37847709›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023

BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance.

Lauren J Donoghue, Matthew R Markovetz, Cameron B Morrison, Gang Chen, Kathryn M McFadden, Taraneh Sadritabrizi, Mark I Gutay, Takafumi Kato, Troy D Rogers, Jazmin Y Snead and 6 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Lauren J DonoghueDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Matthew R MarkovetzMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.ORCID 0000-0003-3931-0594
Cameron B MorrisonMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.ORCID 0000-0002-4031-9521
Gang ChenMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Kathryn M McFaddenDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Taraneh SadritabriziMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Mark I GutayMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Takafumi KatoMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.ORCID 0000-0003-2248-3376
Troy D RogersMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Jazmin Y SneadMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Alessandra Livraghi-ButricoMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.ORCID 0000-0001-8751-3631
Brian ButtonMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Camille EhreMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.ORCID 0000-0002-0046-0096
Barbara R GrubbMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
David B HillMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.ORCID 0000-0002-9270-777X
Samir N P KeladaDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.ORCID 0000-0003-2676-9232
University of North Carolina at Chapel Hill · US

Funding

The Biophysics of Mucus Hydration and Adhesion/CohesionP01HL108808 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESIMER, MEHMET · 2012 to 2021
$23.9M
Project 4: Biophysical and structural characterization of airway submucosal gland mucus in health and diseaseP01HL164320 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Charles Boucher, Michael Rubinstein · 2022 to 2026
$13.9M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
The role of mucus and pulmonary surface interactions in lung defenseR01HL125280 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUTTON, BRIAN M · 2015 to 2023
$3.1M
Systems-level transcriptomic analyses to Identify mouse models of asthmaR01HL122711 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KELADA, SAMIR · 2015 to 2018
$2.0M
Genetic and Longitudinal Analysis of Airway RemodelingF31HL143853 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DONOGHUE, LAUREN · 2018 to 2020
$100k
NHLBI NIH HHS F31 HL143853NHLBI NIH HHS P01 HL108808NHLBI NIH HHS P01 HL164320NHLBI NIH HHS R01 HL122711NHLBI NIH HHS R01 HL125280NIGMS NIH HHS T32 GM007092
6 · The paper itself

Abstract

Airway mucociliary clearance (MCC) is required for host defense and is often diminished in chronic lung diseases. Effective clearance depends upon coordinated actions of the airway epithelium and a mobile mucus layer. Dysregulation of the primary secreted airway mucin proteins, MUC5B and MUC5AC, is associated with a reduction in the rate of MCC; however, how other secreted proteins impact the integrity of the mucus layer and MCC remains unclear. We previously identified the gene

Indexed as

Lung DiseasesMucociliary ClearanceAnimalsHumansMiceMice, KnockoutMucusRespiratory Systemmucinmucociliary clearancemucusrheologyviscoelasticity

Identifiers

PMID37847709
PMCPMC11068428
OpenAlexW4387701269

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.