Evidence map›Paper›PMID 37848608›Full record

ArticleCommunications medicine2023

Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized

Le Zhang, Michael Antonacci, Alex Burant, Andrew McCallister, Michele Kelley, Nicholas Bryden, Christian McHugh, Sebastian Atalla, Leah Holmes, Laurence Katz and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Le Zhang *Department of Physics and Astronomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA.
Michael Antonacci *Department of Physics and Astronomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-9363-3234
Alex Burant *Department of Physics and Astronomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA.
Andrew McCallisterDepartment of Physics and Astronomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA.
Michele KelleyDepartment of Physics and Astronomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA.
Nicholas BrydenDepartment of Physics and Astronomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA.
Christian McHughDepartment of Physics and Astronomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-5668-2088
Sebastian AtallaDepartment of Physics and Astronomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA.
Leah HolmesDepartment of Physics and Astronomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA.
Laurence KatzDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA.
Rosa Tamara BrancaDepartment of Physics and Astronomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA. rtbranca@unc.edu.ORCID http://orcid.org/0000-0002-6871-1824
University of North Carolina at Chapel Hill · US

Funding

Sensitive and Specific detection of BAT Tissue and Activity by Magnetic Resonance with Hyperpolarized Xe-129R01DK108231 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRANCA, ROSA TAMARA · 2015 to 2019
$1.6M
Enabling accurate identification and quantification of brown adipose tissue mass by xenon enhanced computed tomographyR01DK123206 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRANCA, ROSA TAMARA · 2020 to 2021
$866k
NIDDK NIH HHS R01 DK108231NIDDK NIH HHS R01 DK123206
6 · The paper itself

Abstract

backgroundAbsolute temperature measurements of tissues inside the human body are difficult to perform non-invasively. Yet, for brown adipose tissue (BAT), these measurements would enable direct monitoring of its thermogenic activity and its association with metabolic health.

methodsHere, we report direct measurement of absolute BAT temperature in humans during cold exposure by magnetic resonance (MR) with laser polarized xenon gas. This methodology, which leverages on the sensitivity of the chemical shift of the

resultsAbsolute temperature measurements, obtained in rodents with an experimental error of 0.5 °C, show only a median deviation of 0.12 °C against temperature measurements made using a pre-calibrated optical temperature probe. In humans, enhanced uptake of

conclusionsNon-invasive, radiation-free measurements of BAT temperature by MRI with hyperpolarized

Identifiers

PMID37848608
PMCPMC10582175
OpenAlexW4387705276

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.