Evidence map›Paper›PMID 37849047›Full record

ArticleThe Journal of comparative neurology2024

Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala.

Nandkishore Prakash, Heidi Y Matos, Sonia Sebaoui, Luke Tsai, Tuyen Tran, Adejimi Aromolaran, Isabella Atrachji, Nya Campbell, Meredith Goodrich, David Hernandez-Pineda and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of comparative neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Nandkishore PrakashCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.ORCID 0000-0003-1619-3057
Heidi Y MatosCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.ORCID 0000-0002-5486-0773
Sonia SebaouiCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.ORCID 0000-0002-8920-6202
Luke TsaiCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.ORCID 0000-0002-8787-5277
Tuyen TranCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Adejimi AromolaranCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Isabella AtrachjiCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Nya CampbellCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Meredith GoodrichCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
David Hernandez-PinedaCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Maria Jesus HerreroCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.ORCID 0000-0001-7432-3468
Tsutomu HirataCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Julieta LischinskyCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.ORCID 0000-0003-1664-6642
Wendolin MartinezCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Shisui ToriiCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Satoshi YamashitaCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Hassan HosseiniDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-2702-6994
Katie SokolowskiCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Shigeyuki EsumiCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Yuka Imamura KawasawaDepartment of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-8638-6738
Kazue Hashimoto-ToriiCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.
Kevin S JonesDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-5281-1591
Joshua G CorbinCenter for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, District of Columbia, USA.ORCID 0000-0003-0122-4324
Children's National · USUniversity of Michigan · USPennsylvania State University · US

Funding

Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WILLIAM Davis GAILLARD · 2021 to 2026
$9.3M
Development of the Basal Telencephalic Limbic SystemR01DA020140 · NIDA · GEORGETOWN UNIVERSITY · PI CORBIN, JOSHUA G · 2006 to 2020
$7.3M
Cellular and transcriptomic programs linking amygdala progenitors to mature neuronal identityR21MH129995 · NIMH · CHILDREN'S RESEARCH INSTITUTE · PI CORBIN, JOSHUA G, HAYDAR, TARIK F · 2022 to 2023
$594k
NICHD NIH HHS P50 HD105328NIDA NIH HHS R01 DA020140NIMH NIH HHS R21 MH129995
6 · The paper itself

Abstract

In terrestrial vertebrates, the olfactory system is divided into main (MOS) and accessory (AOS) components that process both volatile and nonvolatile cues to generate appropriate behavioral responses. While much is known regarding the molecular diversity of neurons that comprise the MOS, less is known about the AOS. Here, focusing on the vomeronasal organ (VNO), the accessory olfactory bulb (AOB), and the medial amygdala (MeA), we reveal that populations of neurons in the AOS can be molecularly subdivided based on their ongoing or prior expression of the transcription factors Foxp2 or Dbx1, which delineate separate populations of GABAergic output neurons in the MeA. We show that a majority of AOB neurons that project directly to the MeA are of the Foxp2 lineage. Using single-neuron patch-clamp electrophysiology, we further reveal that in addition to sex-specific differences across lineage, the frequency of excitatory input to MeA Dbx1- and Foxp2-lineage neurons differs between sexes. Together, this work uncovers a novel molecular diversity of AOS neurons, and lineage and sex differences in patterns of connectivity.

Indexed as

Corticomedial Nuclear ComplexVomeronasal OrganAnimalsFemaleGABAergic NeuronsMaleOlfactory BulbSex Characteristicsaccessory olfactory systemDbx1Foxp2medial amygdalaolfactory neuronal diversitysex differencesvomeronasal organ

Identifiers

PMID37849047
PMCPMC10922300
OpenAlexW4387728897

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.