Evidence map›Paper›PMID 37852142›Full record

ArticleClinics (Sao Paulo, Brazil)2023

An increase in a long noncoding RNA ANRIL in peripheral plasma is an indicator of stable angina.

Yunjuan Jiao, Fanming Meng, Gaoen Ma, Hetian Lei, Junwen Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yunjuan JiaoDepartment of Histology and Embryology, School of Basic Medical Sciences, Central South University, China; Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, China.
Fanming MengSchool of Forensic, School of Basic Medical Sciences, Central South University, China.
Gaoen MaDepartment of Ophthalmology, The First Affiliated Hospital of Hainan Medical University, China. Electronic address: 15757826611@163.com.
Hetian LeiShenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, China. Electronic address: leihetian18@hotmail.com.
Junwen LiuDepartment of Histology and Embryology, School of Basic Medical Sciences, Central South University, China; China-Africa Research Center of Infectious Diseases, School of Basic Medical Sciences, Central South University, Hunan Province, China. Electronic address: liujunwen@csu.edu.cn.
Central South University · CNHainan Medical University · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionStable angina develops during physical activity or stress, and it is typically an aspect of Coronary Heart Disease (CHD) that can lead to arrhythmia, heart failure and even sudden death. ANRIL, an Antisense Noncoding RNA gene in the INK4 Locus, is associated with multiple disorders including CHD; however, expressional levels of ANRIL in between patients with stable angina and myocardial infarction, one of the acute coronary syndrome, have not been clarified yet.

methodsThe authors enrolled 62 patients with myocardial infarction and 59 with stable angina before primary percutaneous coronary intervention, as well as 48 healthy volunteers. Their peripheral blood was collected for analysis of ANRIL and cardiac troponin I, a traditional diagnostic index of CHD by real-time PCR.

resultsThe data showed that ANRIL is a better diagnostic indicator than cardiac troponin I in patients with stable angina and that the levels of ANRIL are higher in patients with stable angina than those with the myocardial infarction. DISCUSSION: The levels of ANRIL in peripheral plasma could be used as a good biomarker for stable angina.

Indexed as

Angina, StableMyocardial InfarctionRNA, Long NoncodingHumansRNA, AntisenseTroponin IRNA, AntisenseRNA, Long NoncodingTroponin IAcute coronary syndromeANRILCoronary heart diseaseMyocardial infarctionStable angina

Identifiers

PMID37852142
PMCPMC10585623
OpenAlexW4387682381

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.