Evidence map›Paper›PMID 37852782›Full record

ArticleGenome research2023

Characterization of human transcription factor function and patterns of gene regulation in HepG2 cells.

Belle A Moyers, E Christopher Partridge, Mark Mackiewicz, Michael J Betti, Roshan Darji, Sarah K Meadows, Kimberly M Newberry, Laurel A Brandsmeier, Barbara J Wold, Eric M Mendenhall and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. The Encyclopedia of DNA Elements.bioRxiv : the preprint server for biology · 2026
    Article
  2. Promoter mutagenesis and a massively parallel reporter screen of thebioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Belle A MoyersHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.ORCID 0009-0009-4381-7540
E Christopher PartridgeHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Mark MackiewiczHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Michael J BettiVanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Roshan DarjiHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Sarah K MeadowsHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Kimberly M NewberryHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Laurel A BrandsmeierHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Barbara J WoldMerkin Institute for Translational Research, California Institute of Technology, Pasadena, California 91125, USA.
Eric M MendenhallHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA; rmyers@hudsonalpha.org emendenhall@hudsonalpha.org.
Richard M MyersHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA; rmyers@hudsonalpha.org emendenhall@hudsonalpha.org.
HudsonAlpha Institute for Biotechnology · USCalifornia Institute of Technology · USVanderbilt University Medical Center · US

Funding

Higher Precision Human and Mouse TranscriptomesUM1HG009443 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MORTAZAVI, SEYED ALI, WOLD, BARBARA J · 2017 to 2021
$15.5M
An ENCODE ChIP-seq pipeline using endogenously tagged human DNA-associated proteinsUM1HG009411 · NHGRI · HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY · PI MENDENHALL, ERIC, MYERS, RICHARD M · 2017 to 2021
$8.8M
NHGRI NIH HHS UM1 HG009411NHGRI NIH HHS UM1 HG009443
6 · The paper itself

Abstract

Transcription factors (TFs) are

Indexed as

Transcription FactorsBinding SitesChromatinGene Expression RegulationGenome, HumanHep G2 CellsHumansPromoter Regions, GeneticChromatinTranscription Factors

Identifiers

PMID37852782
PMCPMC10760452
OpenAlexW4387735261

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.