Evidence map›Paper›PMID 37855709›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2024

Effects of Systemic Peroxisome Proliferator-Activated Receptor Gamma Inhibition on Bone and Immune Cells in Aged Female Mice.

Xingming Shi, Kehong Ding, Raysa Rosario, Ashwin Ajith, Yun Su, Sean Shaw, Meghan McGee-Lawrence, Xin-Yun Lu, Anatolij Horuzsko, Carlos M Isales

Abstract read
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In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xingming ShiDepartment of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA.ORCID 0000-0003-4920-0989
Kehong DingDepartment of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA.
Raysa RosarioDepartment of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA.
Ashwin AjithCenter for Molecular Chaperone/Radiobiology and Cancer Virology, Augusta University, Augusta, Georgia, USA.
Yun SuDepartment of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA.
Sean ShawDepartment of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA.
Meghan McGee-LawrenceDepartment of Cellular Biology and Anatomy, Augusta University, Augusta, Georgia, USA.
Xin-Yun LuDepartment of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA.
Anatolij HoruzskoCenter for Molecular Chaperone/Radiobiology and Cancer Virology, Augusta University, Augusta, Georgia, USA.
Carlos M IsalesDepartment of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA.

Funding

Inflammation and bone loss with agingR01AG046248 · NIA · AUGUSTA UNIVERSITY · PI SHI, XINGMING · 2013 to 2017
$1.1M
Modulation of Age-Related Inflammation by PPARR56AG066052 · NIA · AUGUSTA UNIVERSITY · PI SHI, XINGMING · 2020 to 2020
$559k
NIA NIH HHS R01 AG046248NIA NIH HHS R56 AG066052NIH HHS R01 AG046248
6 · The paper itself

Abstract

This study investigates the effects of peroxisome proliferator-activated receptor gamma (PPARγ) inhibition on bone and immune cell profiles in aged female mice, as well as in vitro stromal stem cell osteogenic differentiation and inflammation gene expression. The hypothesis was that inhibition of PPARγ would increase bone mass and alter immune and other cellular functions. Our results showed that treatment with PPARγ antagonist GW9662 for 6 weeks reduced bone volume and trabecular number and increased trabecular spacing. However, inhibition of PPARγ had no significant effect on marrow and spleen immune cell composition in aged female mice. In vitro experiments indicated that GW9662 treatment increased the expression of osteogenic genes but did not affect adipogenic genes. Additionally, GW9662 treatment decreased the expression of several inflammation-related genes. Overall, these findings suggest that PPARγ inhibition may have adverse effects on bone in aged female mice.

Indexed as

AnilidesOsteogenesisPPAR gammaAdipogenesisAgingAnimalsBone and BonesFemaleInflammationMice2-chloro-5-nitrobenzanilideAnilidesPPAR gammaAgingBone lossHematopoietic skewPPARγ

Identifiers

PMID37855709
PMCPMC10799761

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.