Evidence map›Paper›PMID 37857256›Full record

ArticleBioorganic & medicinal chemistry2023

Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification.

Lennart Brewitz, H T Henry Chan, Petra Lukacik, Claire Strain-Damerell, Martin A Walsh, Fernanda Duarte, Christopher J Schofield

Open access · hybridAbstract read
In one paragraph

Article in Bioorganic & medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lennart BrewitzChemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, United Kingdom; The Ineos Oxford Institute for Antimicrobial Research, Department of Chemistry, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, United Kingdom. Electronic address: lennart.brewitz@chem.ox.ac.uk.
H T Henry ChanChemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, United Kingdom.
Petra LukacikDiamond Light Source Ltd., Harwell Science and Innovation Campus, OX11 0DE Didcot, United Kingdom; Research Complex at Harwell, Harwell Science and Innovation Campus, OX11 0FA Didcot, United Kingdom.
Claire Strain-DamerellDiamond Light Source Ltd., Harwell Science and Innovation Campus, OX11 0DE Didcot, United Kingdom; Research Complex at Harwell, Harwell Science and Innovation Campus, OX11 0FA Didcot, United Kingdom.
Martin A WalshDiamond Light Source Ltd., Harwell Science and Innovation Campus, OX11 0DE Didcot, United Kingdom; Research Complex at Harwell, Harwell Science and Innovation Campus, OX11 0FA Didcot, United Kingdom.
Fernanda DuarteChemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, United Kingdom.
Christopher J SchofieldChemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, United Kingdom; The Ineos Oxford Institute for Antimicrobial Research, Department of Chemistry, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, United Kingdom. Electronic address: christopher.schofield@chem.ox.ac.uk.
Diamond Light Source · GBMansfield University · USUniversity of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BB/J003018/1Biotechnology and Biological Sciences Research Council BB/R000344/1Cancer Research UK C8717/A18245Wellcome TrustWellcome Trust 106244/Z/14/Z
6 · The paper itself

Abstract

The SARS-CoV-2 papain-like protease (PL

Indexed as

COVID-19LysineCoronavirus Papain-Like ProteasesDeubiquitinating EnzymesHumansOligopeptidesSARS-CoV-2UbiquitinViral ProteinsCoronavirus Papain-Like ProteasesDeubiquitinating EnzymesLysineOligopeptidespapain-like protease, SARS-CoV-2UbiquitinViral ProteinsDeubiquitinase / DUBeIF4E-homologous protein / 4EHPInterferon regulatory factor 3 / IRF3Interferon stimulated gene 15 / ISG15Mass spectrometryNucleophilic cysteine proteaseSARS-CoV-2 papain-like protease / PL(pro)UbiquitinUbiquitin-like modifierVirus-host interactions

Identifiers

PMID37857256
PMCPMC10933793
OpenAlexW4387575899

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.