ReviewFrontiers in immunology2023
Biological significance of C-reactive protein, the ancient acute phase functionary.
Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Prognostic and clinicopathological value of C-reactive protein in patients with bladder cancer: a meta-analysis.Annals of medicine · 2025Pooled it
- Pooled it
- Meta-analysis for the associations of serum C-reactive protein with delirium risk.Frontiers in neurologyPooled it
- Perioperative comparison between robotic-assisted and freehand total knee arthroplasty : A quasi-randomized controlled trial.Orthopadie (Heidelberg, Germany) · 2026Trial
- Novel inflammatory indices compared with CRP for diagnosing pelvic inflammatory disease: a case-control study.BMC women's health · 2026Article
- C-Reactive Protein Trajectories by Summary Metric Across the Coronavirus-2019 Period: A 16-Year Interrupted Time-Series Analysis (2008-2023).Diagnostics (Basel, Switzerland) · 2026Article
- Ileostoma as a promising tool in pathophysiological study and clinical intervention: a review from bench to beside.Frontiers in immunology · 2026Review
- Article
- Admission-measured C-reactive Protein-to-albumin Ratio as a Predictive Marker for Hospital-acquired Infections in Patients with Spontaneous Intracerebral Hemorrhage.Current neurovascular research · 2026Article
- Association between Paleolithic diet fraction and systemic low-grade chronic inflammation in the Malmö diet and cancer study cohort.European journal of nutrition · 2025Article
- Low-grade inflammation score (INFLA- score) associated with metabolic syndrome and its components in shift workers.Diabetology & metabolic syndrome · 2025Article
- Neuronal Count, Brain Injury, and Sustained Cognitive Function in 5×FAD Alzheimer's Disease Mice Fed DHA-Enriched Diets.Biomolecules · 2025Article
- The Role of C-Reactive Protein in Acute Myocardial Infarction: Unmasking Diagnostic, Prognostic, and Therapeutic Insights.Journal of clinical medicine · 2025Review
- Association Between Malnutrition and Multi-Drug Resistant Bacterial Infections in Neurosurgical Intensive Care Unit Patients.Infection and drug resistance · 2025Article
- Article
- Harnessing the host response for precision infectious disease diagnosis.Clinical microbiology reviews · 2024Review
- Neutrophil diversity and function in health and disease.Signal transduction and targeted therapy · 2024Review
- The efficacy of nebulized budesonide and ambroxol hydrochloride in treating pediatric community-acquired pneumonia and their impact on clinical characteristics and inflammatory markers.Journal of health, population, and nutrition · 2024Article
- The Role of Melatonin in the Inflammatory Process in Patients with Hyperglycemia and Leishmania Infection.Biomolecules · 2024Article
- Pentraxin-3 and Outcomes in CKD: A Systematic Review and Meta-analysis.Kidney medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-reactive protein (CRP) is one of the major members of the family of acute phase proteins (APP). Interest in this CRP was the result of a seminal discovery of its pattern of response to pneumococcal infection in humans. CRP has the unique property of reacting with phosphocholine-containing substances, such as pneumococcal C-polysaccharide, in the presence of Ca
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.