Evidence map›Paper›PMID 37860758›Full record

ArticleiScience2023

Distinct mechanisms drive sequential internalization and degradation of GABA

Joshua D Garcia, Sarah E Wolfe, Amber R Stewart, Erika Tiemeier, Sara E Gookin, Mayra Bueno Guerrero, Nidia Quillinan, Katharine R Smith

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Perampanel as a candidate for polytherapy in Stage 1 Plus status epilepticus: biological rationale and translational limits.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Joshua D GarciaDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Sarah E WolfeDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Amber R StewartDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Erika TiemeierDepartment of Anesthesiology, Neuronal Injury Program, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO 80045, USA.
Sara E GookinDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Mayra Bueno GuerreroDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Nidia QuillinanDepartment of Anesthesiology, Neuronal Injury Program, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO 80045, USA.
Katharine R SmithDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
University of Colorado Anschutz Medical Campus · US

Funding

Sex Steroids and Brain Outcome from Cardiac Arrest/Cardiopulmonary ResuscitationR01NS046072 · NINDS · UNIVERSITY OF COLORADO DENVER · PI HERSON, PACO S, QUILLINAN, NIDIA · 2002 to 2024
$7.0M
Local translation mechanisms to control inhibitory synaptic plasticityR01MH128199 · NIMH · UNIVERSITY OF COLORADO DENVER · PI SMITH, KATHARINE RACHEL · 2022 to 2025
$2.5M
Nanoscale organization of the inhibitory synapse during synaptic plasticityR01MH119154 · NIMH · UNIVERSITY OF COLORADO DENVER · PI SMITH, KATHARINE RACHEL · 2020 to 2024
$2.0M
The role of dendritic excitatibility in controlling GABAergic synapse maturationK00MH134674 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Joshua Daylon Garcia · 2023 to 2026
$324k
Understanding the temporal regulation of inhibitory synapse depression and elimination in the context of cerebral ischemiaF99NS120640 · NINDS · UNIVERSITY OF COLORADO DENVER · PI GARCIA, JOSHUA DAYLON · 2021 to 2022
$72k
NIMH NIH HHS K00 MH134674NIMH NIH HHS R01 MH119154NIMH NIH HHS R01 MH128199NINDS NIH HHS F99 NS120640NINDS NIH HHS R01 NS046072
6 · The paper itself

Abstract

Synaptic inhibition is critical for controlling neuronal excitability and function. During global cerebral ischemia (GCI), inhibitory synapses are rapidly eliminated, causing hyper-excitability which contributes to cell-death and the pathophysiology of disease. Sequential disassembly of inhibitory synapses begins within minutes of ischemia onset: GABA

Indexed as

Cellular neuroscienceMolecular physiology

Identifiers

PMID37860758
PMCPMC10582478
OpenAlexW4387035526

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.