Evidence map›Paper›PMID 37861365›Full record

ReviewJournal of medical virology2023

Human papillomaviruses: Knowns, mysteries, and unchartered territories.

Maya K Gelbard, Karl Munger

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of medical virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. A splice donor inJournal of virology · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maya K GelbardGenetics, Molecular and Cellular Biology Program, Graduate School of Biomedical Sciences, Boston, Massachusetts, USA.
Karl MungerGenetics, Molecular and Cellular Biology Program, Graduate School of Biomedical Sciences, Boston, Massachusetts, USA.
Tufts University · US

Funding

Mouse Model of Human Papillomavirus PathogenesisR01CA228543 · NCI · TUFTS UNIVERSITY BOSTON · PI LAMBERT, PAUL F., MUNGER, KARL · 2019 to 2023
$2.3M
Regulation of the Human Papillomavirus Life Cycle by the Long Noncoding RNA DINOR01AI170633 · NIAID · TUFTS UNIVERSITY BOSTON · PI Karl Munger · 2023 to 2026
$1.7M
Mechanistic studies on the unique set of accessory proteins encoded by the gamma 6 human papillomavirusesR21AI166786 · NIAID · TUFTS UNIVERSITY BOSTON · PI MUNGER, KARL · 2021 to 2022
$446k
NCI NIH HHS R01 CA228543NIAID NIH HHS R01 AI170633NIAID NIH HHS R21 AI166786
6 · The paper itself

Abstract

There has been an explosion in the number of papillomaviruses that have been identified and fully sequenced. Yet only a minute fraction of these has been studied in any detail. Most of our molecular research efforts have focused on the E6 and E7 proteins of "high-risk," cancer-associated human papillomaviruses (HPVs). Interactions of the high-risk HPV E6 and E7 proteins with their respective cellular targets, the p53 and the retinoblastoma tumor suppressors, have been investigated in minute detail. Some have thus questioned if research on papillomaviruses remains an exciting and worthwhile area of investigation. However, fundamentally new insights on the biological activities and cellular targets of the high-risk HPV E6 and E7 proteins have been discovered and previously unstudied HPVs have been newly associated with human diseases. HPV infections continue to be an important cause of human morbidity and mortality and since there are no antivirals to combat HPV infections, research on HPVs should remain attractive to new investigators and biomedical funding agencies, alike.

Indexed as

NeoplasmsOncogene Proteins, ViralPapillomavirus InfectionsHuman Papillomavirus VirusesHumansPapillomaviridaePapillomavirus E7 ProteinsOncogene Proteins, ViralPapillomavirus E7 Proteinshuman papillomaviruspersistent infectionsignaling pathwaysviral oncogenesisviral oncoproteinsviral replication

Identifiers

PMID37861365
PMCPMC10608791
OpenAlexW4387799207

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.