ArticleBioinformatics (Oxford, England)2023
Explainable Multilayer Graph Neural Network for cancer gene prediction.
Article in Bioinformatics (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Breaking through the radiation dilemma: development and clinical translation of anti-radiation drugs.Pharmaceutical science advances · 2026Review
- Image-Driven Multimodal Deep Learning for Skin Cancer Diagnosis: Cross-Attention Fusion of Dermoscopic Imaging Clinical Data and Knowledge Graphs.Sensors (Basel, Switzerland) · 2026Article
- Sparsity is all you need: rethinking biologically informed neural networks.Briefings in bioinformatics · 2026Article
- Graph Neural Networks for Medical Imaging Analysis and Biological Data: Integrating Topology, Geometry, Radiomics, and Generative AI.Bioengineering (Basel, Switzerland) · 2026Review
- Artificial intelligence models: transforming early diagnosis and precise treatment of gastrointestinal cancers.Molecular cancer · 2026Review
- GRAFT: a graph-aware fusion transformer for cancer driver gene prediction.Briefings in bioinformatics · 2026Article
- Accurate prediction of candidate lncRNAs associated with DNA damage response based on gene expression patterns from graph neural networks.Bioinformatics advances · 2026Article
- Recent advances in deep learning for leukemia diagnosis: a scoping review of diagnostic modalities and fusion-based approaches.Frontiers in digital health · 2026Review
- Using Biological Networks to Guide Biomedical Prediction.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Multilayer network approaches to omics data integration in digital twins for cancer research.Frontiers in systems biology · 2026Review
- Design biology and mind-body health.Journal, genetic engineering & biotechnology · 2025Review
- Causality-aware graph neural networks for functional stratification and phenotype prediction at scale.NPJ systems biology and applications · 2025Article
- DGHNN: a deep graph and hypergraph neural network for pan-cancer related gene prediction.Bioinformatics (Oxford, England) · 2025Article
- GNNMutation: a heterogeneous graph-based framework for cancer detection.BMC bioinformatics · 2025Article
- Immuno-oncology recapitulates ontogeny: Modern cell and gene therapy for cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Comparative Analysis of Multi-Omics Integration Using Graph Neural Networks for Cancer Classification.IEEE access : practical innovations, open solutions · 2025Article
- Enhancing Molecular Network-Based Cancer Driver Gene Prediction Using Machine Learning Approaches: Current Challenges and Opportunities.Journal of cellular and molecular medicine · 2025Review
- Designing interpretable deep learning applications for functional genomics: a quantitative analysis.Briefings in bioinformatics · 2024Review
- Multimodal data integration for oncology in the era of deep neural networks: a review.Frontiers in artificial intelligence · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
motivationThe identification of cancer genes is a critical yet challenging problem in cancer genomics research. Existing computational methods, including deep graph neural networks, fail to exploit the multilayered gene-gene interactions or provide limited explanations for their predictions. These methods are restricted to a single biological network, which cannot capture the full complexity of tumorigenesis. Models trained on different biological networks often yield different and even opposite cancer gene predictions, hindering their trustworthy adaptation. Here, we introduce an Explainable Multilayer Graph Neural Network (EMGNN) approach to identify cancer genes by leveraging multiple gene-gene interaction networks and pan-cancer multi-omics data. Unlike conventional graph learning on a single biological network, EMGNN uses a multilayered graph neural network to learn from multiple biological networks for accurate cancer gene prediction.
resultsOur method consistently outperforms all existing methods, with an average 7.15% improvement in area under the precision-recall curve over the current state-of-the-art method. Importantly, EMGNN integrated multiple graphs to prioritize newly predicted cancer genes with conflicting predictions from single biological networks. For each prediction, EMGNN provided valuable biological insights via both model-level feature importance explanations and molecular-level gene set enrichment analysis. Overall, EMGNN offers a powerful new paradigm of graph learning through modeling the multilayered topological gene relationships and provides a valuable tool for cancer genomics research. AVAILABILITY AND IMPLEMENTATION: Our code is publicly available at https://github.com/zhanglab-aim/EMGNN.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.