Evidence map›Paper›PMID 37864122›Full record

ArticleLeukemia2023

RAS-pathway mutations are common in patients with ruxolitinib refractory/intolerant myelofibrosis: molecular analysis of the PAC203 cohort.

J M O'Sullivan, J Taylor, A Gerds, S Buckley, C N Harrison, S Oh, A F List, K Howard, H Dreau, A Hamblin and 1 more

Open access · hybridAbstract readLetter
In one paragraph

Article in Leukemia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Polycythaemia vera.Nature reviews. Disease primers · 2025
    Review
  4. Article
  5. Molecular profiling in MPN: who should have it and why?Hematology. American Society of Hematology. Education Program · 2024
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

J M O'SullivanNIHR Biomedical Research Centre and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. jennifer.osullivan@rdm.ox.ac.uk.
J TaylorAstex Pharmaceuticals, Inc., Pleasanton, CA, USA.
A GerdsLeukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-3422-1309
S BuckleyCTI BioPharma Corp., Seattle, WA, USA.
C N HarrisonDepartment of Clinical Haematology, Guy's and St Thomas NHS Foundation Trust, London, UK.
S OhWashington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-8564-5400
A F ListPrecision BioSciences, Inc., Durham, NC, USA.
K HowardDepartment of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID http://orcid.org/0000-0003-3335-4940
H DreauDepartment of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
A HamblinNIHR Biomedical Research Centre and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
A J MeadNIHR Biomedical Research Centre and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. adam.mead@imm.ox.ac.uk.ORCID http://orcid.org/0000-0001-8522-1002
University of Oxford · GBOxford University Hospitals NHS Trust · GBAstex PharmaceuticalsCleveland Clinic · USCTI BioPharma (United States) · USGuy's and St Thomas' NHS Foundation Trust · GBPrecision BioSciences (United States) · USWashington University in St. Louis · US

Funding

Cancer Research UK 26988Cancer Research UK 27125Cancer Research UK 27723Medical Research Council G84/6443Medical Research Council MR/L006340/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Primary MyelofibrosisHumansMutationNitrilesPyrazolesPyrimidinesTreatment OutcomeNitrilesPyrazolesPyrimidinesruxolitinib

Identifiers

PMID37864122
PMCPMC10681886
OpenAlexW4387810660

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.