Evidence map›Paper›PMID 37864716›Full record

ArticleJournal of neurology2024

Cardiac sympathetic "morbidity" might reflect the neurobiology of early Parkinson's disease.

Sang-Won Yoo, Yoon-Sang Oh, Dong-Woo Ryu, Seunggyun Ha, Chul Hyoung Lyoo, Yuna Kim, Ji-Yeon Yoo, Joong-Seok Kim

Abstract read
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In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sang-Won YooDepartment of Neurology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.ORCID http://orcid.org/0000-0002-7988-0228
Yoon-Sang OhDepartment of Neurology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.ORCID http://orcid.org/0000-0002-1566-6265
Dong-Woo RyuDepartment of Neurology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.ORCID http://orcid.org/0000-0003-3390-4607
Seunggyun HaDivision of Nuclear Medicine, Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-2016-1373
Chul Hyoung LyooDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-2231-672X
Yuna KimDepartment of Neurology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.ORCID http://orcid.org/0000-0003-3210-8019
Ji-Yeon YooDepartment of Neurology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.ORCID http://orcid.org/0000-0003-1969-8309
Joong-Seok KimDepartment of Neurology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. neuronet@catholic.ac.kr.ORCID http://orcid.org/0000-0001-8087-7977

Funding

Korea National Institute of Health 2021-ER1008-02National Research Foundation of Korea NRF-2017R1D1A1B06028086National Research Foundation of Korea NRF-2021R1I1A1A01050492
6 · The paper itself

Abstract

backgroundAn appropriate extracranial biomarker that delineates endophenotypes of Parkinson's disease (PD) at an early stage and reflects the neurodegenerative process is lacking. An evaluation of myocardial sympathetic nerve terminals could be a good candidate. This study aimed to explore subtypes of PD patients that showed cardiac catecholaminergic vesicular defect and their characteristics.

methodsThis study included 122 early drug-naïve PD patients who were followed for approximately 4-5 years. All patients were examined with

resultsThis study found that cross-sectional comparisons of presynaptic monoamine transporter availability with a predefined order of cardiac denervation groups revealed parallel degeneration. A quadratic correlation between cardiac catecholamine capacity and cognition was observed. This association was interpreted to reflect the early neurobiology of PD.

conclusionAn observed cardiac catecholaminergic gradient was to mirror the central neurobiology of early PD.

Indexed as

Parkinson Disease3-IodobenzylguanidineCross-Sectional StudiesHeartHumansPositron-Emission Tomography3-Iodobenzylguanidine123I-MIBG myocardial scintigraphyCardiac sympathetic vesiculopathyCompensatory neurobiologyIntermediate cardiac denervationParkinson’s disease

Identifiers

PMID37864716

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.