Evidence map›Paper›PMID 37866248›Full record

ArticleEpilepsy & behavior : E&B2023

Application of the International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) to frontal lobe epilepsy using multicenter data.

Kayela Arrotta, Sara J Swanson, Julie K Janecek, Marla J Hamberger, William B Barr, Sallie Baxendale, Carrie R McDonald, Anny Reyes, Bruce P Hermann, Robyn M Busch

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A user's guide for the International Classification of Cognitive Disorders in Epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2024
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kayela ArrottaEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: arrottk@ccf.org.
Sara J SwansonDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Julie K JanecekDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Marla J HambergerDepartment of Neurology, Columbia University, New York, NY, USA.
William B BarrDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.
Sallie BaxendaleDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Carrie R McDonaldCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA; Department of Radiation Medicine and Applied Sciences, University of California, San Diego, CA, USA.
Anny ReyesCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA; Department of Radiation Medicine and Applied Sciences, University of California, San Diego, CA, USA.
Bruce P HermannDepartment of Neurology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Robyn M BuschEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Funding

Cortical Localization in Temporal Lobe EpilepsyR01NS035140 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HAMBERGER, MARLA J · 2003 to 2022
$5.3M
Multimodal imaging of memory in epilepsy from whole brain networks to local neuronal responses: Implications for surgical decision-makingR01NS124585 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2022 to 2025
$3.3M
NINDS NIH HHS R01 NS035140NINDS NIH HHS R01 NS124585
6 · The paper itself

Abstract

rationaleThe International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) was recently introduced as a consensus-based, empirically-driven taxonomy of cognitive disorders in epilepsy and has been effectively applied to patients with temporal lobe epilepsy (TLE). The purpose of this study was to apply the IC-CoDE to patients with frontal lobe epilepsy (FLE) using national multicenter data.

methodsNeuropsychological data of 455 patients with FLE aged 16 years or older were available across four US-based sites. First, we examined test-specific impairment rates across sites using two impairment thresholds (1.0 and 1.5 standard deviations below the normative mean). Following the proposed IC-CoDE guidelines, patterns of domain impairment were determined based on commonly used tests within five cognitive domains (language, memory, executive functioning, attention/processing speed, and visuospatial ability) to construct phenotypes. Impairment rates and distributions across phenotypes were then compared with those found in patients with TLE for which the IC-CoDE classification was initially validated.

resultsThe highest rates of impairment were found among tests of naming, verbal fluency, speeded sequencing and set-shifting, and complex figure copy. The following IC-CoDE phenotype distributions were observed using the two different threshold cutoffs: 23-40% cognitively intact, 24-29% single domain impairment, 13-20% bi-domain impairment, and 18-33% generalized impairment. Language was the most common single domain impairment (68% for both thresholds) followed by attention and processing speed (15-18%). Overall, patients with FLE reported higher rates of cognitive impairment compared with patients with TLE.

conclusionsThese results demonstrate the applicability of the IC-CoDE to epilepsy syndromes outside of TLE. Findings indicated generally stable and reproducible phenotypes across multiple epilepsy centers in the U.S. with diverse sample characteristics and varied neuropsychological test batteries. Findings also highlight opportunities for further refinement of the IC-CoDE guidelines as the application expands.

Indexed as

Cognition DisordersCognitive DysfunctionEpilepsy, Frontal LobeEpilepsy, Temporal LobeCognitionExecutive FunctionHumansNeuropsychological TestsCognitionEpilepsyFrontal lobe epilepsyNeuropsychologyPhenotypes

Identifiers

PMID37866248
PMCPMC11467825

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.