ReviewFrontiers in molecular neuroscience2023
Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction.
Review in Frontiers in molecular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Corticospinal effects and motor performance changes following resistance training in healthy adults: a systematic review and meta-analysis of transcranial magnetic stimulation.Frontiers in physiology · 2026Pooled it
- Short-Lived Exercise-Induced Exerkines Modulate Inflammation for Chronic Disease Prevention: A Systematic Review and Meta-Analysis.Biomolecules · 2025Pooled it
- Effects of exercise on executive function in individuals with drug addiction: a systematic review and three-level meta-analysis.Frontiers in sports and active living · 2025Pooled it
- Effect of exercise on brain-derived neurotrophic factors in middle-aged and older adults with type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Time-dependent comparison of serum BDNF responses following high-intensity interval exercise and moderate- and low-intensity continuous exercise in healthy young men.Scientific reports · 2026Trial
- Positive effects of functional electrical stimulation-assisted cycling on perception of effort, cerebral blood flow, and cognition in post-stroke patients.Journal of neuroengineering and rehabilitation · 2025Trial
- Voluntary Exercise and Hippocampal Memory Enhancement: Decoding the Molecular Blueprint.Journal of molecular neuroscience : MN · 2026Review
- Do Physical Exercises and Physical Activity Generate Positive Effects on Sleep Quality and Urinary Incontinence in Menopausal Women? A Systematic Review with Meta-Analysis.Journal of menopausal medicine · 2026Review
- Biochemical Pathways of Neuroplasticity in Sport Skill Acquisition: From Neuroscience to Coaching Practice.Brain sciences · 2026Review
- Exercise-associated changes in leptin and irisin relate to cognitive function in older adults stratified by cognitive impairment.Scientific reports · 2026Article
- Mind-body exercise as epigenetic modulators: Rewiring neural circuits for stress resilience and cognitive aging.IBRO neuroscience reports · 2026Review
- Translational Insights into Exercise-Induced Protective Adaptations in 5XFAD Mice and Middle-Aged Amateur Sportsmen.Antioxidants (Basel, Switzerland) · 2026Article
- Molecules of mood: the integrated molecular transducers of exercise's antidepressant effects.Molecular genetics and genomics : MGG · 2026Review
- SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential.Neuromolecular medicine · 2026Review
- Sleep Duration and Physical Activity as Predictors of Executive Function in Adolescents: A Longitudinal Study.Brain sciences · 2026Article
- Cognitive impairment caused by compromised hepatic ketogenesis is prevented by endurance exercise.The Journal of physiology · 2026Article
- Immediate and Long-Term Effectiveness of a Therapeutic Exercise Protocol in Patients with Dementia.Journal of clinical medicine · 2026Article
- Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats.Experimental physiology · 2026Article
- Enhancement of response learning in male rats with intrastriatal infusions of a BDNF -TrkB agonist, 7,8-dihydroxyflavone.Behavioural brain research · 2026Article
- Myokine Cathepsin B as a Key Muscle-Brain Axis Regulator Mediates Treadmill-Running-Induced Hippocampal Neurogenesis and Cognitive Improvement in Mice.Research (Washington, D.C.) · 2026Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence supports that physical exercise (EX) is the most effective non-pharmacological strategy to improve brain health. EX prevents cognitive decline associated with age and decreases the risk of developing neurodegenerative diseases and psychiatric disorders. These positive effects of EX can be attributed to an increase in neurogenesis and neuroplastic processes, leading to learning and memory improvement. At the molecular level, there is a solid consensus to involve the neurotrophin brain-derived neurotrophic factor (BDNF) as the crucial molecule for positive EX effects on the brain. However, even though EX incontestably leads to beneficial processes through BDNF expression, cellular sources and molecular mechanisms underlying EX-induced cerebral BDNF overproduction are still being elucidated. In this context, the present review offers a summary of the different molecular mechanisms involved in brain's response to EX, with a specific focus on BDNF. It aims to provide a cohesive overview of the three main mechanisms leading to EX-induced brain BDNF production: the neuronal-dependent overexpression, the elevation of cerebral blood flow (hemodynamic hypothesis), and the exerkine signaling emanating from peripheral tissues (humoral response). By shedding light on these intricate pathways, this review seeks to contribute to the ongoing elucidation of the relationship between EX and cerebral BDNF expression, offering valuable insights into the potential therapeutic implications for brain health enhancement.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.