Evidence map›Paper›PMID 37872155›Full record

ArticleNature communications2023

Interferon-γ couples CD8

Lion F K Uhl, Han Cai, Sophia L Oram, Jagdish N Mahale, Andrew J MacLean, Julie M Mazet, Theo Piccirilli, Alexander J He, Doreen Lau, Tim Elliott and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Unique CD8bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. CD8Frontiers in immunology · 2026
    Review
  13. Article
  14. Article
  15. Dysbiosis modulates CD8iScience · 2025
    Article
  16. Article
  17. Article
  18. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  19. Article
  20. SLAMF7 (CD319) on activated CD8Cell death and differentiation · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Lion F K UhlThe Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID 0000-0003-1729-9857
Han CaiThe Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Sophia L OramThe Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Jagdish N MahaleThe Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Andrew J MacLeanThe Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Julie M MazetThe Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Theo PiccirilliThe Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Alexander J HeThe Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Doreen LauCentre for Immuno-oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Tim ElliottCentre for Immuno-oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-1097-0222
Audrey GerardThe Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. audrey.gerard@kennedy.ox.ac.uk.ORCID 0000-0003-3059-3065
University of Oxford · GB

Funding

Cancer Research UK 28279Cancer Research UK 29549
6 · The paper itself

Abstract

Effective responses to intracellular pathogens are characterized by T cell clones with a broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell clones are selected throughout the response to retain a breadth of avidities remains unclear. Here, we demonstrate that direct sensing of the cytokine IFN-γ by CD8

Indexed as

CD8-Positive T-LymphocytesInterferon-gammaCell DifferentiationCytokinesPeptidesCytokinesInterferon-gammaPeptides

Identifiers

PMID37872155
PMCPMC10593754
OpenAlexW4387872968

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.