Evidence map›Paper›PMID 37873120›Full record

ArticlebioRxiv : the preprint server for biology2023

Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome (AGS)-ortholog mutants of

Deepali L Kundnani, Taehwan Yang, Alli L Gombolay, Kuntal Mukherjee, Gary Newnam, Chance Meers, Zeel H Mehta, Celine Mouawad, Francesca Storici

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Deepali L KundnaniSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Taehwan YangSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Alli L GombolaySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Kuntal MukherjeeSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Gary NewnamSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Chance MeersSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Zeel H MehtaSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Celine MouawadSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Francesca StoriciSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Georgia Institute of Technology · USCenters for Disease Control and Prevention · US

Funding

Ribose-seq profile and analysis of ribonucleotides in DNA of oxidatively-stressed and cancer cellsR01ES026243 · NIEHS · GEORGIA INSTITUTE OF TECHNOLOGY · PI STORICI, FRANCESCA · 2016 to 2020
$1.4M
NIEHS NIH HHS R01 ES026243
6 · The paper itself

Abstract

Ribonucleoside monophosphates (rNMPs) are abundantly found within genomic DNA of cells. The embedded rNMPs alter DNA properties and impact genome stability. Mutations in ribonuclease (RNase) H2, a key enzyme for rNMP removal, are associated with the Aicardi-Goutières syndrome (AGS), a severe neurological disorder. Here, we engineered two AGS-ortholog mutations in

Identifiers

PMID37873120
PMCPMC10592897
OpenAlexW4387305783

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.