Evidence map›Paper›PMID 37873213›Full record

ArticlebioRxiv : the preprint server for biology2023

Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Diseases.

Jason C Collins, Samuel J Magaziner, Maya English, Bakar Hassan, Xiang Chen, Nicholas Balanda, Meghan Anderson, Athena Lam, Sebastian Fernandez-Pol, Bernice Kwong and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Jason C CollinsStem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research, National institutes of Health, Bethesda, MD.
Samuel J MagazinerCenter for Human Genetics and Genomics, New York University School of Medicine, New York, NY.
Maya EnglishStem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research, National institutes of Health, Bethesda, MD.
Bakar HassanProtein Processing Section, Center for Structural Biology, National Cancer Institute, National Institutes of Health, Frederick, MD.
Xiang ChenProtein Processing Section, Center for Structural Biology, National Cancer Institute, National Institutes of Health, Frederick, MD.
Nicholas BalandaCenter for Human Genetics and Genomics, New York University School of Medicine, New York, NY.
Meghan AndersonCenter for Human Genetics and Genomics, New York University School of Medicine, New York, NY.
Athena LamCenter for Human Genetics and Genomics, New York University School of Medicine, New York, NY.
Sebastian Fernandez-PolDepartment of Pathology, Stanford University Medical School, Stanford, California, USA.
Bernice KwongDepartment of Dermatology, Stanford University Cancer Center, Stanford, CA, USA.
Peter L GreenbergDivision of Hematology, Stanford University Cancer Center, Stanford, California, USA.
Benjamin TerrierDepartment of Internal Medicine, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris.
Mary E LikhiteCenter for Human Genetics and Genomics, New York University School of Medicine, New York, NY.
Olivier KosmiderLaboratory of Hematology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris.
Yan WangMass Spectrometry Facility, National Institute of Dental and Craniofacial Research, National institutes of Health, Bethesda, MD.
Nadine L SamaraStructural Biochemistry Unit, National Institute of Dental and Craniofacial Research, National institutes of Health, Bethesda, MD.
Kylie J WaltersProtein Processing Section, Center for Structural Biology, National Cancer Institute, National Institutes of Health, Frederick, MD.
David B BeckCenter for Human Genetics and Genomics, New York University School of Medicine, New York, NY.
Achim WernerStem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research, National institutes of Health, Bethesda, MD.
Center for Human Genetics · USNational Institute of Dental and Craniofacial Research · USNational Institutes of Health · USStanford University · USHôpital Cochin · FR

Funding

Ubiquitin signaling for protein degradationZIABC011490 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WALTERS, KYLIE · 2013 to 2025
$21.1M
Ubiquitin-dependent cell-fate decisions during human development and diseaseZIADE000749 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI WERNER, ACHIM · 2018 to 2025
$14.1M
Gene Transfer Core, NIDCR-DIRZICDE000744 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI KULKARNI, ASHOK · 2014 to 2023
$12.1M
Understanding the Role of Somatic Mutations in Adult Inflammatory DiseasesR00AR078205 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BECK, DAVID · 2022 to 2024
$740k
Intramural NIH HHS ZIA BC011490Intramural NIH HHS ZIA DE000749Intramural NIH HHS ZIC DE000744NIAMS NIH HHS R00 AR078205
6 · The paper itself

Abstract

Most cellular ubiquitin signaling is initiated by UBA1, which activates and transfers ubiquitin to tens of E2 enzymes. Clonally acquired

Indexed as

E2 enzymelung cancer in never smokersnon-canonical VEXAS mutationsUBA1ubiquitinVEXAS syndromeX-linked spinal muscular atrophy

Identifiers

PMID37873213
PMCPMC10592724
OpenAlexW4387536356

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.