Evidence map›Paper›PMID 37873285›Full record

ArticlebioRxiv : the preprint server for biology2023

Large genetic analysis of alcohol resistance and tolerance reveals an inverse correlation and suggests 'true' tolerance mutants.

Maggie M Chvilicek, Alexandra Seguin, Daniel R Lathen, Iris Titos, Pearl N Cummins-Beebe, Miguel A Pabon, Masa Miscevic, Emily A Nickel, Collin B Merrill, Aylin R Rodan and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Maggie M ChvilicekDepartment of Psychiatry, Huntsman Mental Health Institute, School of Medicine, University of Utah, Salt Lake City, USA.ORCID 0000-0002-9270-0906
Alexandra SeguinMolecular Medicine Program, School of Medicine, University of Utah, Salt Lake City, USA.ORCID 0000-0001-8492-9084
Daniel R LathenDepartment of Psychiatry, Huntsman Mental Health Institute, School of Medicine, University of Utah, Salt Lake City, USA.ORCID 0000-0003-3373-5110
Iris TitosDepartment of Psychiatry, Huntsman Mental Health Institute, School of Medicine, University of Utah, Salt Lake City, USA.ORCID 0000-0002-5542-3794
Pearl N Cummins-BeebeDepartment of Psychiatry, Huntsman Mental Health Institute, School of Medicine, University of Utah, Salt Lake City, USA.ORCID 0000-0001-5909-1312
Miguel A PabonMolecular Medicine Program, School of Medicine, University of Utah, Salt Lake City, USA.ORCID 0009-0003-4905-0607
Masa MiscevicMolecular Medicine Program, School of Medicine, University of Utah, Salt Lake City, USA.
Emily A NickelMolecular Medicine Program, School of Medicine, University of Utah, Salt Lake City, USA.
Collin B MerrillDepartment of Psychiatry, Huntsman Mental Health Institute, School of Medicine, University of Utah, Salt Lake City, USA.ORCID 0000-0002-7968-2707
Aylin R RodanMolecular Medicine Program, School of Medicine, University of Utah, Salt Lake City, USA.ORCID 0000-0001-9202-2378
Adrian RothenfluhDepartment of Psychiatry, Huntsman Mental Health Institute, School of Medicine, University of Utah, Salt Lake City, USA.ORCID 0000-0002-3813-5723
University of Utah · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI KEVIN R COOK · 2014 to 2026
$13.5M
Control of Alcohol Responses by Actin-Regulating GenesR01AA019526 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHENFLUH, ADRIAN · 2010 to 2025
$5.4M
Regulation of WNK signaling by potassium and Mo25: structure, function and physiologyR01DK110358 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RODAN, AYLIN RACHEL · 2016 to 2025
$4.1M
Mechanisms of alcohol-induced plasticitey mediated by Arf6R01AA026818 · NIAAA · UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2018 to 2022
$1.7M
Chromatin remodeling in GABA neurons contributes to alcohol use disorderK01AA029200 · NIAAA · UNIVERSITY OF UTAH · PI MERRILL, COLLIN · 2022 to 2024
$470k
Genetic, molecular, and neural mechanisms of alcohol-induced effects on sleepF31AA030209 · NIAAA · UNIVERSITY OF UTAH · PI CHVILICEK, MARGARET · 2022 to 2024
$113k
NIAAA NIH HHS F31 AA030209NIAAA NIH HHS K01 AA029200NIAAA NIH HHS R01 AA019526NIAAA NIH HHS R01 AA026818NIDDK NIH HHS R01 DK110358NIH HHS P40 OD018537
6 · The paper itself

Abstract

Tolerance occurs when, following an initial experience with a substance, more of the substance is required subsequently to induce the same behavioral effects. Tolerance is historically not well-understood, and numerous researchers have turned to model organisms, particularly

Indexed as

Drosophilaethanolgeneticssensitivitytolerance

Identifiers

PMID37873285
PMCPMC10592763
OpenAlexW4387476338

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.