ArticlemedRxiv : the preprint server for health sciences2023
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.
Open access · greenAbstract readPreprint
In one paragraph
Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 30 citations in OpenAlex.
- [Next-generation phenotyping in rare diseases with facial dysmorphism].Innere Medizin (Heidelberg, Germany) · 2023Review
Corrections and comments
- Updated by
Authors and funding
87 authors at 20 institutions in 9 countries.
Nick DandDepartment of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Philip E StuartDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
John BowesCentre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.
David EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Joanne NitithamDeparment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Jake R SaklatvalaDepartment of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Maris Teder-LavingInstitute of Genomics, University of Tartu, Tartu, Estonia.
Laurent F ThomasDepartment of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Tanel TraksDepartment of Dermatology and Venereology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Steffen UebeInstitute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Gunter AssmannRUB University Hospital JWK Minden, Department of Rheumatology, Minden, Germany.
David BaudrySt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Frank BehrensDivision of Translational Rheumatology, Immunology - Inflammation Medicine, University Hospital, Goethe University, Frankfurt am Main, Germany.
Allison C BilliDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Matthew A BrownDepartment of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Harald BurkhardtDivision of Rheumatology, University Hospital, Goethe University, Frankfurt am Main, Germany.
Francesca CaponDepartment of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Raymond ChungInstitute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.
Charles J CurtisInstitute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.
Michael DuckworthSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Eva EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Oliver FitzGeraldUCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland.
Sascha GerdesDepartment of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Christopher E M GriffithsCentre for Dermatology Research, University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester, UK.
Susanne GulliverNewlab Clinical Research Inc, St. John's, NL, Canada.
Philip HelliwellNational Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, UK.
Pauline HoCentre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.
Per HoffmannInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Oddgeir L HolmenHUNT Research Centre, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Levanger, Norway.
Zhi-Ming HuangDeparment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Deepak JadonDepartment of Medicine, University of Cambridge, Cambridge, UK.
Michaela KöhmDivision of Translational Rheumatology, Immunology - Inflammation Medicine, University Hospital, Goethe University, Frankfurt am Main, Germany.
Cornelia KrausInstitute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Céline LamacchiaDivision of Rheumatology, Geneva University Hospital, Geneva, Switzerland.
Sang Hyuck LeeInstitute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.
Feiyang MaDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Satveer K MahilSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Neil McHughRoyal National Hospital for Rheumatic Diseases and Dept Pharmacy and Pharmacology, University of Bath, UK.
Ross McManusDepartment of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland.
Ellen H ModalsliDepartment of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Michael J NissenDivision of Rheumatology, Geneva University Hospital, Geneva, Switzerland.
Markus NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Vinzenz OjiDepartment of Dermatology, University of Münster, Münster, Germany.
Jorge R OksenbergWeill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
Matthew T PatrickDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Bethany E Perez-WhiteDepartment of Dermatology, Northwestern University, Evanston, IL, USA.
Andreas RammingDepartment of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Jürgen RechDepartment of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Cheryl RosenDivision of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Mrinal K SarkarDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Georg SchettDepartment of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Börge SchmidtInstitute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Trilokraj TejasviDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Heiko TraupeDepartment of Dermatology, University of Münster, Münster, Germany.
John J VoorheesDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Eike Matthias WackerInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Richard B WarrenDivision of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, UK.
Rachael WasikowskiDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Stephan WeidingerDepartment of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Xiaoquan WenDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Zhaolin ZhangDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
BSTOP study group
Estonian Biobank research team
Anne BartonCentre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.
Vinod ChandranSchroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Tõnu EskoInstitute of Genomics, University of Tartu, Tartu, Estonia.
John FoersterCollege of Medicine, Dentistry, and Nursing, University of Dundee, Dundee, UK.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Dafna D GladmanSchroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Johann E GudjonssonDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Wayne GulliverNewlab Clinical Research Inc, St. John's, NL, Canada.
Ulrike HüffmeierInstitute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Külli KingoDepartment of Dermatology and Venereology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Sulev KõksPerron Institute for Neurological and Translational Science, Nedlands, WA 6009, Australia.
Wilson LiaoDeparment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Mari LøsetK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Rajan P NairDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Proton RahmanMemorial University of Newfoundland, St. John's, NL, Canada.
André ReisInstitute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Catherine H SmithSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Paola Di MeglioSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Jonathan N BarkerSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Lam C TsoiDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Michael A SimpsonDepartment of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
James T ElderDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
King's College London · GBUniversity of Michigan · USNational Health Service · GBNorwegian University of Science and Technology · NOMemorial University of Newfoundland · CAUniversity Health Network · CAUniversity of California, San Francisco · USChristian-Albrechts-Universität zu Kiel · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGoethe University Frankfurt · DEUniversity of Manchester · GBMurdoch University · AUUniversitätsklinikum Erlangen · DEUniversity Hospital of Geneva · CHUniversity Hospital Schleswig-Holstein · DEUniversity of Bonn · DEUniversity of Dundee · GBUniversity of Münster · DEUniversity of Tartu · EEManchester Academic Health Science Centre · GB
Funding
Linkage analysis of familial psoriasis(Supplement)R01AR042742 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 1994 to 2021
$10.1MUniversity of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDRZEJ A. DLUGOSZ · 2019 to 2026
$6.6MGenetic and Genomic Dissection of Psoriatic ArthritisR01AR063611 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD, GLADMAN, DAFNA D · 2012 to 2023
$6.2MIdentification of Psoriatic Arthritis Genes in the MHCR01AR050511 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2004 to 2013
$4.2MMHC and KIR Region Genomics in PsoriasisU01AI119125 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2015 to 2019
$3.5MImmunogenomics and Systems Biology CoreUC2AR081033 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson, Lam Cheung Tsoi · 2022 to 2026
$3.3MCombined Analysis of Gene Expression and DNA Variation in PsoriasisR01AR054966 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2007 to 2011
$3.2MFunctional genomics of GxE in cardiovascular disease: BPA, phthalates and their interactions with gene regulationR01ES033634 · NIEHS · WAYNE STATE UNIVERSITY · PI Francesca Luca, Roger Pique-Regi · 2022 to 2026
$2.5MResolving Methodological Challenges in Genomics Research: Causality, Risk Prediction, and Reproducibility: Administrative SupplementR35GM138121 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Xiaoquan Wen · 2020 to 2026
$2.4MIdentification of Causal Variants in PsoriasisR01AR065174 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2013 to 2016
$1.8MFunctional Genomics of PsoriasisR01AR065183 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2013 to 2016
$1.7MMechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathwayK08AR078251 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BILLI, ALLISON CHELSA · 2021 to 2025
$865kMedical Research Council MR/S003126/1NIAID NIH HHS U01 AI119125NIAMS NIH HHS K01 AR072129NIAMS NIH HHS K08 AR078251NIAMS NIH HHS P30 AR075043NIAMS NIH HHS R01 AR042742NIAMS NIH HHS R01 AR050511NIAMS NIH HHS R01 AR054966NIAMS NIH HHS R01 AR063611NIAMS NIH HHS R01 AR065174NIAMS NIH HHS R01 AR065183NIAMS NIH HHS UC2 AR081033NIEHS NIH HHS R01 ES033634NIGMS NIH HHS R35 GM138121
Abstract
Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not fully explained by variation at robustly identified risk loci. To move towards a saturation map of psoriasis susceptibility we meta-analysed 18 GWAS comprising 36,466 cases and 458,078 controls and identified 109 distinct psoriasis susceptibility loci, including 45 that have not been previously reported. These include susceptibility variants at loci in which the therapeutic targets IL17RA and AHR are encoded, and deleterious coding variants supporting potential new drug targets (including in
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.