Evidence map›Paper›PMID 37873439›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Discovery of Ancestry-specific Variants Associated with Clopidogrel Response among Caribbean Hispanics.

Guang Yang, Pablo González, Mariangeli Moneró, Kelvin Carrasquillo, Jessicca Y Renta, Dagmar F Hernandez-Suarez, Mariana R Botton, Kyle Melin, Stuart A Scott, Gualberto Ruaño and 5 more

Registry-linked trialOpen access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03419325 (Adopting a Precision Medicine Paradigm in Puerto Rico), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03419325 early_phase1completednot on this map

Adopting a Precision Medicine Paradigm in Puerto Rico: Leveraging Ancestral Diversity to Identify Predictors of Clopidogrel Response in Caribbean Hispanics

TypeinterventionalSponsorUniversity of Puerto RicoRan2020 to 2025Enrolled150ConditionsCardiovascular Disease (CVD), Stroke, Acute Coronary Syndrome, Peripheral Arterial DiseaseArmsCYP2C19 test, P2RY12 assay
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Guang YangDepartment of Pharmacology, Center for Pharmacogenomics, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, United States.
Pablo GonzálezDepartment of Pharmacology, School of Medicine, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, 00936, United States.
Mariangeli MoneróDepartment of Pharmacology, School of Medicine, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, 00936, United States.
Kelvin CarrasquilloResearch Centers in Minority Institutions (RCMI) Program, Center for Collaborative Research in Health Disparities (CCRHD), Academic Affairs Deanship, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, 00936, United States.
Jessicca Y RentaResearch Centers in Minority Institutions (RCMI) Program, Center for Collaborative Research in Health Disparities (CCRHD), Academic Affairs Deanship, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, 00936, United States.
Dagmar F Hernandez-SuarezDepartment of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, United States.
Mariana R BottonTransplant Immunology and Personalized Medicine Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Kyle MelinDepartment of Pharmacy Practice, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, 00936, United States.
Stuart A ScottDepartment of Pathology, Stanford University, Palo Alto, CA 94304, United States.
Gualberto RuañoInstitute of Living at Hartford Hospital, Hartford, CT 06102, United States.
Abiel Roche-LimaResearch Centers in Minority Institutions (RCMI) Program, Center for Collaborative Research in Health Disparities (CCRHD), Academic Affairs Deanship, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, 00936, United States.
Cristina AlarconDepartment of Pharmacology, Center for Pharmacogenomics, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, United States.
Marylyn D RitchieDepartment of Genetics and Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, United States.
Minoli A PereraDepartment of Pharmacology, Center for Pharmacogenomics, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, United States.
Jorge DucongeResearch Centers in Minority Institutions (RCMI) Program, Center for Collaborative Research in Health Disparities (CCRHD), Academic Affairs Deanship, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, 00936, United States.
University of Puerto Rico, Medical Sciences Campus · PRNorthwestern University · USFlorida International University · USHartford Hospital · USHospital de Clínicas de Porto Alegre · BRPalo Alto University · USUniversity of Pennsylvania · US

Funding

SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jose R. Rodriguez-Medina · 2012 to 2026
$52.9M
Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Carmen M Velez Vega · 2017 to 2026
$35.8M
RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54MD007587 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., NOBOA, CARIAMARIE · 2012 to 2018
$23.2M
African American Cardiovascular pharmacogenetic CONsorTium (ACCOuNT): discovery and translationU54MD010723 · NIMHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MELTZER, DAVID O, PERERA, MINOLI A · 2016 to 2020
$9.5M
NIGMS NIH HHS P20 GM103475NIGMS NIH HHS R25 GM061838NIMHD NIH HHS U54 MD007587NIMHD NIH HHS U54 MD007600NIMHD NIH HHS U54 MD010723
6 · The paper itself

Abstract

Background: High on-treatment platelet reactivity (HTPR) with clopidogrel is predictive of ischemic events in adults with coronary artery disease. Despite strong data suggesting HTPR varies with ethnicity, including clinical and genetic variables, no genome-wide association study (GWAS) of clopidogrel response has been performed among Caribbean Hispanics. This study aimed to identify genetic predictors of HTPR in a cohort of Caribbean Hispanic cardiovascular patients from Puerto Rico. Methods: Local Ancestry inference (LAI) and traditional GWASs were performed on a cohort of 511 clopidogrel-treated patients, stratified based on their P2Y12 reaction units (PRU) into responders and non-responders (HTPR). Results: The LAI GWAS identified variants within the Conclusion: This is the first GWAS of clopidogrel response in Hispanics, confirming the relevance of the

Indexed as

Caribbean HispanicsClopidogrelGenome-wide AssociationPharmacogenomicsPlatelet Reactivity

Identifiers

PMID37873439
PMCPMC10593031
OpenAlexW4387245971

What Socratic holds

Textmetadata
LicenceCC BY-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.