Evidence map›Paper›PMID 37873456›Full record

ArticlebioRxiv : the preprint server for biology2023

A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers.

Janice M Thompson, Stephanie W Watts, Leah Terrian, G Andres Contreras, Cheryl Rockwell, C Javier Rendon, Emma Wabel, Lizabeth Lockwood, Sudin Bhattacharya, Rance Nault

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Janice M ThompsonDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Stephanie W WattsDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Leah TerrianDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.
G Andres ContrerasDepartment of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA.
Cheryl RockwellDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
C Javier RendonDepartment of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA.
Emma WabelDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Lizabeth LockwoodDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Sudin BhattacharyaDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.
Rance NaultDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, USA.
Michigan State University · USIndividual Differences · US

Funding

The perivascular adipocyte: integrating mechanical and structural cues into vasoactive functionP01HL152951 · NHLBI · MICHIGAN STATE UNIVERSITY · PI Stephanie W Watts · 2022 to 2026
$13.3M
Integrative Pharmacological Sciences Training Program (IPSTP)T32GM142521 · NIGMS · MICHIGAN STATE UNIVERSITY · PI ANNE M. DORRANCE, Gina Marie Leinninger · 2021 to 2026
$2.4M
NHLBI NIH HHS P01 HL152951NIGMS NIH HHS T32 GM142521
6 · The paper itself

Abstract

Perivascular adipose tissue (PVAT) is increasingly recognized for its function in mechanotransduction. To examine the cell-specificity of recognized mechanotransducers we used single nuclei RNA sequencing (snRNAseq) of the thoracic aorta PVAT (taPVAT) from male Dahl SS rats compared to subscapular brown adipose tissue (BAT). Approximately 30,000 nuclei from taPVAT and BAT each were characterized by snRNAseq, identifying 8 major cell types expected and one unexpected (nuclei with oligodendrocyte marker genes). Cell-specific differential gene expression analysis between taPVAT and BAT identified up to 511 genes (adipocytes) with many (≥20%) being unique to individual cell types.

Indexed as

brown adipose tissueDahl SS ratmechanotransductionPerivascular adipose tissuePiezo1single-nuclei RNA sequencing

Identifiers

PMID37873456
PMCPMC10592719
OpenAlexW4387500238

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.