Evidence map›Paper›PMID 37874883›Full record

ArticleScience signaling2023

Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint.

Shankar K Revu, Wenjuan Yang, Dhivyaa Rajasundaram, Alexander Brady, Saikat Majumder, Sarah L Gaffen, William Hawse, Zongqi Xia, Mandy J McGeachy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Heat-killedResearch square · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shankar K RevuDivision of Rheumatology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0009-0003-0323-7628
Wenjuan YangDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14850, USA.ORCID 0009-0005-0607-1058
Dhivyaa RajasundaramDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Alexander BradyDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0002-4177-5203
Saikat MajumderDivision of Rheumatology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-6591-9515
Sarah L GaffenDivision of Rheumatology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-8511-2041
William HawseDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-8371-3345
Zongqi XiaDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15261 USA.ORCID 0000-0003-1500-2589
Mandy J McGeachyDivision of Rheumatology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-5029-1668
University of Pittsburgh · USCornell University · US

Funding

Leveraging electronic health records to optimize treatment selection and response in multiple sclerosisR01NS098023 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Zongqi Xia · 2016 to 2026
$4.6M
Network of Excellence in Neuroscience Clinical Trials (University of Pittsburgh CRS)U24NS107166 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Paula R Clemens · 2018 to 2026
$3.3M
Molecular Mechanisms of IL-17-dependent autoimmune signalingR01AI147383 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2020 to 2024
$2.6M
IL-17 regulates LN stromal cell metabolism and functionR01AI148356 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCGEACHY, MANDY J · 2020 to 2023
$1.8M
Real-world impact of the COVID-19 pandemic in people with multiple sclerosisR01NS124882 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIA, ZONGQI · 2022 to 2024
$1.2M
NIAID NIH HHS R01 AI147383NIAID NIH HHS R01 AI148356NINDS NIH HHS R01 NS098023NINDS NIH HHS R01 NS124882NINDS NIH HHS U24 NS107166
6 · The paper itself

Abstract

The cytokine interleukin-17 (IL-17) is secreted by T helper 17 (T

Indexed as

Interleukin-17Multiple SclerosisCell DifferentiationCytokinesHumansPhosphotransferases (Alcohol Group Acceptor)Receptors, Antigen, T-CellRNA, MessengerTh17 Cells1-phosphatidylinositol-4-phosphate 5-kinaseCytokinesIL17A protein, humanInterleukin-17Phosphotransferases (Alcohol Group Acceptor)Receptors, Antigen, T-CellRNA, Messenger

Identifiers

PMID37874883
PMCPMC10880140
OpenAlexW4387902029

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.