Evidence mapPaperPMID 37875637Full record

Trial reportEuropean journal of nutrition2024

Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial.

Maria Grazia Vaccaro, Bernardo Innocenti, Erika Cione, Luca Gallelli, Giovambattista De Sarro, Diego A Bonilla, Roberto Cannataro

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria Grazia Vaccaro *Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, Italy.
Bernardo Innocenti *BEAMS Department, Universitè Libre de Bruxelles, Brussels, Belgium.
Erika CioneDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Luca GallelliClinical Pharmacology and Pharmacovigilance Operative Unit, Department of Health Science, University of Magna Graecia, Mater Domini Hospital, Catanzaro, Italy.
Giovambattista De SarroClinical Pharmacology and Pharmacovigilance Operative Unit, Department of Health Science, University of Magna Graecia, Mater Domini Hospital, Catanzaro, Italy.
Diego A BonillaResearch Division, Dynamical Business and Science Society-DBSS International SAS, 110861, Bogotá, Colombia.
Roberto CannataroDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy. rcannataro@nutrics.it.ORCID http://orcid.org/0000-0002-1668-7690

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDietary nitrate (NO

objectiveThe aim of this study was to evaluate the effects of a single dose of a chewable BR-based supplement on cognitive performance.

methodsA double-blind randomized placebo-controlled two-period crossover clinical trial was carried out based on the extension of the CONSORT guidelines for randomized crossover trials. A total of 44 participants (24 F; 20 M; 32.7 [12.5] years; 66.3 [9.0] kg; 170 [9.2] cm; 22.8 [1.4] kg/m

resultsSignificant improvements with moderate effect size were found on memory consolidation at the short and long term only after BR-CT supplementation via the Rey Auditory Verbal Learning Test immediate (+ 20.69%) and delayed (+ 12.34%) recalls. Likewise, enhancement on both frontal lobe functions (+ 2.57%) and cognitive flexibility (+ 11.16%) were detected after BR-CT. There was no significant change (p < 0.05) on verbal memory of short-term digits, working memory and information processing speed. Mixed results were found on mood and anxiety through the Beck Depression Inventory-II (BDI-II) and the State-Trait Anxiety Inventory (STAI-Y1 and STAI-Y2); however, sequence and period effects were seen on STAI-Y2.

conclusionsThe acute administration of a chewable BR-based supplement improves certain aspects of cognitive function in healthy females and males, particularly memory capacity and frontal skills.

Indexed as

Beta vulgarisNitratesAntioxidantsCognitionCross-Over StudiesDietary SupplementsDouble-Blind MethodFemaleHumansMaleAntioxidantsNitratesCognitive functionDietary supplementsNeuropsychological testsNitratesNitric oxide

Identifiers

PMID37875637
PMCPMC10799154

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.