Evidence map›Paper›PMID 37875709›Full record

ArticleMolecular neurobiology2024

In Vitro and In Vivo Supplementation with Curcumin Promotes Hippocampal Neuronal Synapses Development in Rats by Inhibiting GSK-3β and Activating β-catenin.

Yinhong Zhang, Jinghui Yang, Yanling Gong, Shan He, Ping Wen, Yan Jiang, Jing He, Baosheng Zhu, Li Li

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yinhong Zhang *Faculty of Life Science and Biotechnology, Kunming University of Science and Technology, Kunming, 650500, China.
Jinghui Yang *Department of Pediatrics, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
Yanling Gong *School of Medicine, Kunming University of Science and Technology, Kunming, 650500, China.
Shan HeDepartment of Pediatrics, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
Ping WenDepartment of Pediatrics, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
Yan JiangDepartment of Prevention and Healthcare, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
Jing HeDepartment of Medical Genetics, NHC Key Laboratory of Preconception Health Birth in Western China, Yunnan Provincial Key Laboratory for Birth Defects and Genetic Diseases, Yunnan Provincial Clinical Research Center for Birth Defects and Rare Diseases, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
Baosheng ZhuDepartment of Medical Genetics, NHC Key Laboratory of Preconception Health Birth in Western China, Yunnan Provincial Key Laboratory for Birth Defects and Genetic Diseases, Yunnan Provincial Clinical Research Center for Birth Defects and Rare Diseases, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, 650032, China. bszhu@aliyun.com.
Li LiFaculty of Life Science and Biotechnology, Kunming University of Science and Technology, Kunming, 650500, China. kherklili@sina.com.ORCID http://orcid.org/0000-0002-8406-2588
Kunming University of Science and Technology · CN

Funding

Co-operation Fund of Kunming Medical University and the Science and Technology Department of Yunnan Province 202101AY070001-262Famous Doctor special project of the Ten Thousand People Program of Yunnan Province YNWR-MY-2018-016Fund of Yunnan Provincial Clinical Research Center for Birth Defects and Rare Diseases 2019ZF015Innovation Research Project of Human Assisted Reproductive Technology of Yunnan Province 2017HC009Open Fund of Reproductive Obstetrics and Gynecology Clinical Center of Yunnan Province 2022LCZXKF-SZ02Open Fund of Reproductive Obstetrics and Gynecology Clinical Center of Yunnan Province zx2019-01-01Open Fund of Yunnan Provincial Key Laboratory for Birth Defects and Genetic Diseases 2020ZDKFKT001
6 · The paper itself

Abstract

The human fetal thyroid gland is not capable of producing thyroid hormones independently until 20 weeks of gestation, and if maternal thyroid hormone synthesis is inadequate in early pregnancy, fetal brain and nerve development may be affected by maternal hypothyroidism. Curcumin, which is isolated from turmeric (Curcuma longa), has been shown to be effective in repairing neurological disorders and is effective in relieving nerve damage when consumed over a long period of time. In this experiment, we investigated the effect of curcumin supplementation on synaptic development of rat hippocampal neurons. A cell model of oxidative damage and a young rat model of hypothyroidism were constructed, and model cells and rats were treated with triiodothyronine (T3), tetraiodothyronine (T4), and curcumin, respectively. Damage of nerve cells and animal brain tissues was examined, and the effect of curcumin in alleviating the blocked neurodevelopment was investigated. Further modulation of GSK-3β/β-catenin was performed to investigate the mechanism of action of curcumin. Ultimately, we found that T3-, T4-, and curcumin-treated model cells and young rats had increased numbers of synapses and good neurodevelopment. At the same time, we found that curcumin inhibited the production of GSK-3β and Axin to activate β-catenin. The inhibition of β-catenin weakened the therapeutic effect of curcumin, and the differences between the indicators and the model group disappeared. Both cellular and animal experiments supported that curcumin effectively alleviated the oxidative cell damage caused by thyroxine deficiency and activated the synaptogenic ability of nerve synapses by inhibiting GSK-3β and protecting β-catenin activity.

Indexed as

CurcuminHypothyroidismAnimalsbeta CateninDietary SupplementsGlycogen Synthase Kinase 3 betaHippocampusHumansNeuronsRatsSynapsesbeta CateninCurcuminGlycogen Synthase Kinase 3 betaCurcuminGSK-3βHypothyroidismNeuronal synaptic developmentβ-Catenin

Identifiers

PMID37875709
OpenAlexW4387931337

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.