ArticleScience advances2023
Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity.
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
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Who cites it
25 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Circadian clock protein Bmal1 regulates respiratory motor plasticity in male rats.Function (Oxford, England) · 2026Article
- A High-Throughput Live Imaging Platform to Investigate Circuit-Dependent Regulation of Circadian Rhythms in Brain Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Circadian Phase Modulates Embryonic Susceptibility to Bisphenol A-Induced ASD-Related Behavioral Alterations viaToxics · 2026Article
- The astrocyte clock controls circadian perineuronal net remodeling, synapse strength and learning behavior.bioRxiv : the preprint server for biology · 2026Article
- Circadian Changes in CA1 LTP Are Driven by Shifts in Excitation-Inhibition Balance and Reverse Direction after Puberty in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A GABAergic neural circuit from the suprachiasmatic nucleus to DG drives cognitive impairment in migraine mice.The journal of headache and pain · 2026Article
- Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions.Nature reviews. Cardiology · 2026Review
- Circadian rhythms of neuronal and astrocytic glutamate transporters in the suprachiasmatic nucleus of mice.Frontiers in cellular neuroscience · 2026Article
- Circadian rhythms in pediatric neurocritical care: interfaces and opportunities.Frontiers in neurology · 2026Review
- Short-term continuous light exposure induces hippocampal rhythmic and functional alterations: a multi-timepoint metabolomics study.Frontiers in molecular biosciences · 2026Article
- Core Circadian Protein BMAL1: Implication for Nervous System Functioning and Its Diseases.Brain sciences · 2025Review
- Repetitive unidirectional spinal tactile stimulation engages microglial Bmal1 pathways to promote synaptic remodeling in the mPFC of adolescent VPA-exposed mice.Journal of neuroinflammation · 2025Article
- The sleep-wake history contributes to rhythmic BMAL1 chromatin binding in the cerebral cortex but not in the liver.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Circadian Rhythms in Plasticity Markers Are Regulated by the Suprachiasmatic Nucleus and Local Circadian Oscillators in the Rodent Neocortex.Molecular neurobiology · 2025Article
- Review
- Article
- PKA-mediated BMAL1 phosphorylation promotes βiScience · 2025Article
- Mechanistic insights into the interaction between epilepsy and sleep.Nature reviews. Neurology · 2025Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Ilaria BaroneDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-7328-3406
Nicole M GiletteDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-7191-7268
Hannah Hawks-MayerDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.
Jonathan HandyDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-5035-5801
Kevin J ZhangDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-3120-3922
Fortunate F ChifambaDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-0749-8492
Engie MostafaDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0009-0000-2182-0137
Erin M Johnson-VenkateshDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-2590-0737
Yan SunDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.
Jennifer M GibsonDepartments of Neurology, Neuroscience, Pediatrics, and Psychiatry, University of Texas at Southwestern, Dallas, TX 75390, USA.
Alexander RotenbergDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.
Hisashi UmemoriDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-7198-2062
Peter T TsaiDepartments of Neurology, Neuroscience, Pediatrics, and Psychiatry, University of Texas at Southwestern, Dallas, TX 75390, USA.ORCID 0000-0002-0729-9688
Jonathan O LiptonDepartment of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-9648-0541
Boston Children's Hospital · USThe University of Texas Southwestern Medical Center · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MMedical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MHow do neurons in the brain decide to refine their synaptic connections in vivo?R01MH111647 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI Chinfei Chen, Hisashi Umemori · 2017 to 2026
$6.8MCerebellum and cerebellar-regulated circuit contribution to Fragile X Syndrome -R01MH120069 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TSAI, PETER T. · 2020 to 2024
$3.0MEpilepsy Seizure Detection with Innovative Tripolar EEG (tEEG)U44NS121559 · NINDS · CREMEDICAL CORPORATION · PI BESIO, WALTER GRANT · 2021 to 2024
$2.5MMechanisms of Circadian and Synaptic Dysfunction After Repetitive Mild TBIRF1NS126547 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LIPTON, JONATHAN OREN, WHALEN, MICHAEL J · 2022 to 2022
$2.4MInvestigating Circadian Mechanisms of Cellular Resilience: Rhythmic Condensates, Disorder, and StressR01HL151368 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI LIPTON, JONATHAN OREN · 2020 to 2024
$2.1MThe Cellular and Systems Biology of Sleep and Circadian Rhythms Training ProgramT32HL139438 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GREENE, ROBERT W, TAKAHASHI, JOSEPH S · 2018 to 2022
$1.2MNetwork Pharmacology for Epilepsy PreventionR43NS119081 · NINDS · PREVEP, INC. · PI KLEIN, PAVEL · 2021 to 2022
$700kNeurophysiologic investigation of somatosensory dysfunction in Autism Spectrum DisordersR21MH120438 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI ROTENBERG, ALEXANDER · 2020 to 2020
$503kAstrocytic Glutamate Transporter 1 (GLT-1) enhancement for the treatment of seizures in Dravet SyndromeR21NS123459 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI ROTENBERG, ALEXANDER · 2021 to 2021
$487kNHLBI NIH HHS R01 HL151368NHLBI NIH HHS T32 HL139438NICHD NIH HHS P50 HD105351NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NIMH NIH HHS F30 MH132277NIMH NIH HHS R01 MH111647NIMH NIH HHS R01 MH120069NIMH NIH HHS R21 MH120438NINDS NIH HHS R21 NS121858NINDS NIH HHS R21 NS123459NINDS NIH HHS R43 NS119081NINDS NIH HHS RF1 NS126547NINDS NIH HHS U44 NS121559
Abstract
The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. The circadian clock comprises a canonical transcription-translation feedback loop (TTFL) strictly dependent on the BMAL1 transcription factor. We report that BMAL1 rhythmically localizes to hippocampal synapses in a manner dependent on its phosphorylation at Ser
Indexed as
ARNTL Transcription FactorsCircadian ClocksCircadian RhythmHippocampusPhosphorylationARNTL Transcription Factors
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What Socratic holds
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LicenceCC BY-NC
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.