Evidence map›Paper›PMID 37879293›Full record

ArticleCancer epidemiology2023

Hyperemesis gravidarum and the risk of childhood cancer - A case-control study in Denmark.

Helen T Orimoloye, Chuanjie Deng, Johnni Hansen, Jorn Olsen, Chai Saechao, Beate Ritz, Julia E Heck

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Helen T OrimoloyeCollege of Health and Public Service, University of North Texas, 1155 Union Circle # 311340, Denton, TX 76203-5017, USA.
Chuanjie DengDepartment of Epidemiology, Fielding School of Public Health, Box 951772, University of California, Los Angeles, Los Angeles, CA, 900951772 USA.
Johnni HansenDanish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
Jorn OlsenDepartment of Clinical Epidemiology, Aarhus University Hospital, 8200 Aarhus N, Denmark.
Chai SaechaoUCLA Health, University of California, Los Angeles, CA, USA.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, Box 951772, University of California, Los Angeles, Los Angeles, CA, 900951772 USA.
Julia E HeckCollege of Health and Public Service, University of North Texas, 1155 Union Circle # 311340, Denton, TX 76203-5017, USA; Department of Epidemiology, Fielding School of Public Health, Box 951772, University of California, Los Angeles, Los Angeles, CA, 900951772 USA. Electronic address: julia.heck@unt.edu.
University of California, Los Angeles · USUniversity of North Texas · USAarhus University Hospital · DKDanish Cancer Society · DK

Funding

Maternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015
$323k
NCI NIH HHS R21 CA175959
6 · The paper itself

Abstract

objectiveOnly a few studies have reported on the association between hyperemesis gravidarum and the risk of childhood cancer. We examined possible associations in this population-based study in Denmark.

methodsPediatric cancer cases (n = 6420) were ascertained from the Denmark Cancer Registry among children born between 1977 and 2013. Twenty-five controls were matched to each case by sex and birth date from the Central Person Registry (n = 160500). Mothers with hyperemesis gravidarum were ascertained from the National Patient Register. The risk of childhood cancer was estimated using conditional logistic regression. In a separate analysis, we examined pregnancy prescription of antinauseant medications, ascertained from the National Pharmaceutical Register, to determine associations with childhood cancers.

resultsIn Denmark, hyperemesis gravidarum was associated with an increased risk of childhood cancer [all types combined; Odds Ratio (OR) = 1.43, 95% confidence interval (CI) 1.12, 1.81; n = 73 exposed cases). Hyperemesis gravidarum was also associated with an increased risk of neuroblastoma (OR = 2.52, 95% CI 1.00, 6.36; n = 5 exposed cases), acute lymphoblastic leukemia (OR = 1.63, 95% CI 0.98, 2.72; n = 16 exposed cases), and non-Hodgkin's lymphoma (OR = 2.41, 95% CI 0.95, 6.08; n = 5 exposed cases). We observed no childhood cancer risk increase from antinauseant prescriptions (OR = 1.05, 95% CI 0.84, 1.30; n = 91 exposed cases).

conclusionOur results are suggestive of an association between hyperemesis gravidarum and the overall cancer risk in offspring, particularly for neuroblastoma. Mothers with hyperemesis gravidarum should be closely monitored and receive appropriate treatment during pregnancy.

Indexed as

Hyperemesis GravidarumNeuroblastomaCase-Control StudiesChildDenmarkFemaleHumansMothersPregnancyAcute lymphoblasticAntiemeticsAntinauseantsChildhood cancerHyperemesis gravidarumLeukemiaNeuroblastomaNon-Hodgkin's lymphomaPregnancy

Identifiers

PMID37879293
PMCPMC10754053
OpenAlexW4387868587

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.