Evidence map›Paper›PMID 37880206›Full record

ArticleNature communications2023

Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8

Diego Calzada-Fraile, Salvador Iborra, Marta Ramírez-Huesca, Inmaculada Jorge, Enrico Dotta, Elena Hernández-García, Noa Martín-Cófreces, Estanislao Nistal-Villán, Esteban Veiga, Jesús Vázquez and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  3. Article
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  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Targeting tumor metabolism to augment CD8Journal of pharmaceutical analysis · 2025
    Review
  12. Review
  13. Article
  14. Review
  15. Fungal immunization potentiates CD4Frontiers in immunology · 2025
    Article
  16. Recent Advances in Host Immune Mechanisms AgainstJournal of inflammation research · 2025
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Diego Calzada-FraileCentro Nacional de Investigaciones Cardiovasculares, 28029, Madrid, Spain.ORCID http://orcid.org/0000-0001-7259-0757
Salvador IborraDepartment of Immunology, Ophthalmology and ENT, School of Medicine, Universidad Complutense de Madrid, 28040, Madrid, Spain.ORCID http://orcid.org/0000-0002-1607-1749
Marta Ramírez-HuescaCentro Nacional de Investigaciones Cardiovasculares, 28029, Madrid, Spain.
Inmaculada JorgeCentro Nacional de Investigaciones Cardiovasculares, 28029, Madrid, Spain.
Enrico DottaLaboratory of Synthetic Immunology, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Elena Hernández-GarcíaDepartment of Immunology, Ophthalmology and ENT, School of Medicine, Universidad Complutense de Madrid, 28040, Madrid, Spain.
Noa Martín-CófrecesCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029, Madrid, Spain.ORCID http://orcid.org/0000-0003-0439-8979
Estanislao Nistal-VillánMicrobiology Section, Departamento CC, Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU San Pablo, Boadilla del Monte, 28668, Madrid, Spain.ORCID http://orcid.org/0000-0003-2458-8833
Esteban VeigaDepartment of Molecular & Cellular Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-7333-2466
Jesús VázquezCentro Nacional de Investigaciones Cardiovasculares, 28029, Madrid, Spain.ORCID http://orcid.org/0000-0003-1461-5092
Giulia PasqualLaboratory of Synthetic Immunology, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-1476-2669
Francisco Sánchez-MadridCentro Nacional de Investigaciones Cardiovasculares, 28029, Madrid, Spain. fsmadrid@salud.madrid.org.ORCID http://orcid.org/0000-0001-5303-0762
Spanish National Centre for Cardiovascular Research · ESUniversidad Complutense de Madrid · ESUniversity of Padua · ITCentro de Investigación en Red en Enfermedades Cardiovasculares · ESCentro Nacional de Biotecnología · ESEscuela Nacional de Sanidad · ESUniversidad San Pablo CEU · ES

Funding

NIMHD NIH HHS L60 MD007209
6 · The paper itself

Abstract

Antigen cognate dendritic cell (DC)-T cell synaptic interactions drive activation of T cells and instruct DCs. Upon receiving CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesAnimalsAntigen PresentationAntigensDendritic CellsHistocompatibility Antigens Class ILipid PeroxidationMiceMice, Inbred C57BLSynapsesUp-RegulationAntigensHistocompatibility Antigens Class I

Identifiers

PMID37880206
PMCPMC10600134
OpenAlexW4387937460

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.