Evidence map›Paper›PMID 37884534›Full record

ArticleNature communications2023

FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design.

Wern Hann Ng, Xiang Liu, Zheng L Ling, Camilla N O Santos, Lucas S Magalhães, Andrew J Kueh, Marco J Herold, Adam Taylor, Joseph R Freitas, Sandra Koit and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Wern Hann Ng *Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia.
Xiang Liu *Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia.
Zheng L LingViral Immunopathology Laboratory, Infection, Immunity and Inflammation Research Theme, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
Camilla N O SantosDivision of Immunology and Molecular Biology Laboratory, University Hospital/EBSERH, Federal University of Sergipe (UFS), Aracaju, Brazil.
Lucas S MagalhãesDivision of Immunology and Molecular Biology Laboratory, University Hospital/EBSERH, Federal University of Sergipe (UFS), Aracaju, Brazil.ORCID 0000-0002-2169-7463
Andrew J KuehThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Marco J HeroldThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.ORCID 0000-0001-7539-7581
Adam TaylorEmerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia.
Joseph R FreitasEmerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia.
Sandra KoitInstitute of Technology, University of Tartu, Tartu, Estonia.ORCID 0009-0006-3037-1568
Sainan WangInstitute of Technology, University of Tartu, Tartu, Estonia.ORCID 0000-0002-7046-4965
Andrew R LloydViral Immunology Systems Program, Kirby Institute, University of New South Wales, Kensington, NSW, Australia.ORCID 0000-0001-6277-8887
Mauro M TeixeiraInstituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Andres MeritsInstitute of Technology, University of Tartu, Tartu, Estonia.
Roque P AlmeidaDivision of Immunology and Molecular Biology Laboratory, University Hospital/EBSERH, Federal University of Sergipe (UFS), Aracaju, Brazil.
Nicholas J C KingEmerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia.ORCID 0000-0002-3877-9772
Suresh MahalingamEmerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia. s.mahalingam@griffith.edu.au.ORCID 0000-0003-3141-8410
Griffith University · AUUniversidade Federal de Sergipe · BRUniversity of Tartu · EEThe University of Melbourne · AUThe University of Sydney · AUUniversidade Federal de Minas Gerais · BRUNSW Sydney · AU

Funding

GENETIC, BIOCHEMICAL AND DIETARY PROBES OF AGINGR01AG001154 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RUSSELL, RICHARD L · 1985 to 1987
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6 · The paper itself

Abstract

Arthritogenic alphaviruses are positive-strand RNA viruses that cause debilitating musculoskeletal diseases affecting millions worldwide. A recent discovery identified the four-and-a-half-LIM domain protein 1 splice variant A (FHL1A) as a crucial host factor interacting with the hypervariable domain (HVD) of chikungunya virus (CHIKV) nonstructural protein 3 (nsP3). Here, we show that acute and chronic chikungunya disease in humans correlates with elevated levels of FHL1. We generated FHL1

Indexed as

ArthritisChikungunya FeverChikungunya virusVaccinesAnimalsHumansIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMiceMuscle ProteinsO'nyong-nyong VirusFHL1 protein, humanFhl1 protein, mouseIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMuscle ProteinsVaccines

Identifiers

PMID37884534
PMCPMC10603155
OpenAlexW4387958247

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.