ArticleHepatobiliary surgery and nutrition2023
Assessment of long-term graft function following total pancreatectomy and autologous islet transplantation: the Leicester experience.
Article in Hepatobiliary surgery and nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Long Term Metabolic Outcomes Following Pancreatectomy and Autologous Islet Transplantation: Systematic Review and Meta-Analysis.Journal of surgical oncology · 2026Pooled it
- Degree of islet function preservation and continuous glucose monitoring in individuals undergoing total pancreatectomy with islet autotransplantation.Diabetologia · 2026Article
- A narrative review on the evolution of islet isolation techniques and improving yields during total pancreatectomy and islet autotransplantation.Annals of hepato-biliary-pancreatic surgery · 2025Review
- Long-term results of total pancreatectomy and autologous islet transplantation for chronic pancreatitis: total pancreatectomy with autologous islet transplantation (TPAIT) preserves long-term islet graft functions in 10-year follow-up.Hepatobiliary surgery and nutrition · 2025Article
- Future directions based on evaluation of long-term efficacy of total pancreatectomy and autologous islet transplantation.Hepatobiliary surgery and nutrition · 2025Article
- Comparative Analysis of Islet Auto-Transplantation Outcome Classification Systems: Evaluating Concordance, Feasibility, and a Data-Driven Approach.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Total pancreatectomy with islet cell auto-transplantation for chronic pancreatitis: sustaining long-term glycemic health with or without graft function.Hepatobiliary surgery and nutrition · 2024Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Total pancreatectomy and islet autotransplantation (TPIAT) is a recognised treatment for chronic pancreatitis (CP) with the potential to mitigate or prevent pancreatogenic diabetes. We present our 10-year follow-up of TPIAT patients. Methods: The University Hospitals of Leicester performed 60 TPIAT procedures from September 1994 to May 2011. Seventeen patients completed their 10-year assessment and were grouped using the modified Auto-Igls criteria; good response, n=5 (insulin-independent for first 5 years post-TPIAT); partial response, n=6 (insulin requirements <20 iU/day post-TPIAT) and poor response, n=6 (insulin requirements ≥20 iU/day post-TPIAT). C-peptide, haemoglobin A1c (HbA Results: Median C-peptide levels were significantly higher, 120 minutes following OGTT, in the "good response" compared to "partial" and "poor" groups (two-way ANOVA test, P<0.0001). All groups demonstrated preservation of C-peptide release. HbA Conclusions: TPIAT preserves long-term islet graft functions in 10-year follow up. Even in patients in the poor response group, there is evidence of C-peptide release (>0.5 ng/mL) after OGTT stimulation potentially preventing long-term diabetes-related complications.
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