Evidence map›Paper›PMID 37887396›Full record

ArticleMetabolites2023

Urinary Metabolite Profiling to Non-Invasively Monitor the Omega-3 Index: An Exploratory Secondary Analysis of a Randomized Clinical Trial in Young Adults.

Brittany C MacIntyre, Meera Shanmuganathan, Shannon L Klingel, Zachary Kroezen, Erick Helmeczi, Na-Yung Seoh, Vanessa Martinez, Adrian Chabowski, Zeny Feng, Philip Britz-McKibbin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Recent studies confirm the utility of the omega-3 index.Current opinion in clinical nutrition and metabolic care · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brittany C MacIntyreDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0001-6231-4310
Meera ShanmuganathanDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 3W3, Canada.ORCID 0000-0001-9446-6749
Shannon L KlingelDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Zachary KroezenDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 3W3, Canada.ORCID 0000-0001-9415-7604
Erick HelmecziDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 3W3, Canada.
Na-Yung SeohDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 3W3, Canada.
Vanessa MartinezDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 3W3, Canada.ORCID 0009-0008-4262-8089
Adrian ChabowskiDepartment of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland.ORCID 0000-0002-7407-8156
Zeny FengDepartment of Mathematics & Statistics, University of Guelph, Guelph, ON N1G 2W1, Canada.
Philip Britz-McKibbinDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 3W3, Canada.ORCID 0000-0001-9296-3223
David M MutchDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0002-0908-7259

Funding

Ministry of Agriculture, Food and Rural Affairs 2093
6 · The paper itself

Abstract

The Omega-3 Index (O3I) reflects eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) content in erythrocytes. While the O3I is associated with numerous health outcomes, its widespread use is limited. We investigated whether urinary metabolites could be used to non-invasively monitor the O3I in an exploratory analysis of a previous placebo-controlled, parallel arm randomized clinical trial in males and females (

Indexed as

dietary biomarkersmetabolomicsomega-3 indexomega-3 long-chain polyunsaturated fatty acids (n3-LCPUFA)precision nutritionurinary metabolites

Identifiers

PMID37887396
PMCPMC10608872

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.