Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 6 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors at 6 institutions in 2 countries.
Ahmed SalihWilliam Harvey Research Institute, National Institute for Health and Care Research (NIHR) Barts Biomedical Research Centre Queen Mary University of London, Charterhouse Square London United Kingdom.ORCID 0000-0002-0871-8282
Maddalena ArdissinoNational Heart and Lung Institute, Imperial College London London United Kingdom.ORCID 0000-0002-2654-8117
Aaron Z WagenGenetics and Genomic Medicine, Great Ormond Street Institute of Child Health University College London London United Kingdom.ORCID 0000-0002-7747-6870
Andrew BardWilliam Harvey Research Institute, National Institute for Health and Care Research (NIHR) Barts Biomedical Research Centre Queen Mary University of London, Charterhouse Square London United Kingdom.ORCID 0000-0002-5553-8487
Liliana SzaboWilliam Harvey Research Institute, National Institute for Health and Care Research (NIHR) Barts Biomedical Research Centre Queen Mary University of London, Charterhouse Square London United Kingdom.
Mina RytenGenetics and Genomic Medicine, Great Ormond Street Institute of Child Health University College London London United Kingdom.ORCID 0000-0001-9520-6957
Steffen E PetersenWilliam Harvey Research Institute, National Institute for Health and Care Research (NIHR) Barts Biomedical Research Centre Queen Mary University of London, Charterhouse Square London United Kingdom.ORCID 0000-0003-4622-5160
André AltmannCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering University College London London United Kingdom.ORCID 0000-0002-9265-2393
Zahra Raisi-EstabraghWilliam Harvey Research Institute, National Institute for Health and Care Research (NIHR) Barts Biomedical Research Centre Queen Mary University of London, Charterhouse Square London United Kingdom.ORCID 0000-0002-7757-5465
Great Ormond Street Hospital · GBNational Health Service · GBQueen Mary University of London · GBSemmelweis University · HUUniversity College London · GBUniversity of Cambridge · GB
Funding
ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MURRAY, ANNE M · 2019 to 2023
$42.9M
Using genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3M
Whole genome sequences in individuals to comprehensively characterize the genetic mechanisms of dyslipidemiasR01HL142711 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Satoshi Koyama, Gina Marie Peloso · 2019 to 2026
$4.7M
Randomized controlled trial of the effect of low dose aspirin on the course of age-related macular degenerationR01EY026890 · NEI · MONASH UNIVERSITY · PI GUYMER, ROBYN, MCNEIL, JOHN JAMES · 2016 to 2020
$1.6M
British Heart Foundation FS/17/81/33318British Heart Foundation PG/21/10619NEI NIH HHS R01 EY026890NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL142711NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682
6 · The paper itself
Abstract
BACKGROUND Pericardial adipose tissue (PAT) is the visceral adipose tissue compartment surrounding the heart. Experimental and observational research has suggested that greater PAT deposition might mediate cardiovascular disease, independent of general or subcutaneous adiposity. We characterize the genetic architecture of adiposity-adjusted PAT and identify causal associations between PAT and adverse cardiac magnetic resonance imaging measures of cardiac structure and function in 28 161 UK Biobank participants. METHODS AND RESULTS The PAT phenotype was extracted from cardiac magnetic resonance images using an automated image analysis tool previously developed and validated in this cohort. A genome-wide association study was performed with PAT area set as the phenotype, adjusting for age, sex, and other measures of obesity. Functional mapping and Bayesian colocalization were used to understand the biologic role of identified variants. Mendelian randomization analysis was used to examine potential causal links between genetically determined PAT and cardiac magnetic resonance-derived measures of left ventricular structure and function. We discovered 12 genome-wide significant variants, with 2 independent sentinel variants (rs6428792,
Indexed as
Biological Specimen BanksGenome-Wide Association StudyAdipose TissueBayes TheoremHumansIntra-Abdominal FatObesityPericardiumT-Box Domain ProteinsUnited KingdomT-Box Domain ProteinsTBX15 protein, humancardiovascular diseasegenome‐wide association studypericardial adipose tissue
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Genome-Wide Association Study of Pericardial Fat Area in 28 161 UK Biobank Participants. · full record | Socratic