Evidence map›Paper›PMID 37890204›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2023

In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis.

Elias C Padilha, Mengbi Yang, Pranav Shah, Amy Q Wang, Jianmin Duan, Joshua K Park, Charles N Zawatsky, May Christine V Malicdan, George Kunos, Malliga R Iyer and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Elias C PadilhaDrug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA. Electronic address: elias.padilha@nih.gov.
Mengbi YangDrug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA.
Pranav ShahDrug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA.
Amy Q WangDrug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA.
Jianmin DuanInversago Pharma, Montreal, Quebec, Canada.
Joshua K ParkLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Rockville, MD, USA.
Charles N ZawatskyLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Rockville, MD, USA.
May Christine V MalicdanNIH Undiagnosed Diseases Program, UDP Translational Laboratory, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
George KunosLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Rockville, MD, USA.
Malliga R IyerSection on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Rockville, MD 20852, USA.
Geneviève GaucherInversago Pharma, Montreal, Quebec, Canada.
François RavenelleInversago Pharma, Montreal, Quebec, Canada.
Resat CinarSection on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Rockville, MD, USA.
Xin XuDrug Metabolism and Pharmacokinetics Core, National Center for Advancing Translational Sciences, Rockville, MD, USA. Electronic address: xin.xu3@nih.gov.
National Center for Advancing Translational Sciences · USNational Institute on Alcohol Abuse and Alcoholism · USInversago Pharma (Canada) · CANational Institutes of Health · US

Funding

Intramural NIH HHS Z99 TR999999
6 · The paper itself

Abstract

Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder that affects lysosome-related organelles, often leading to fatal pulmonary fibrosis (PF). The search for a treatment for HPS pulmonary fibrosis (HPSPF) is ongoing. S-MRI-1867, a dual cannabinoid receptor 1 (CB

Indexed as

Hermanski-Pudlak SyndromePulmonary FibrosisAnimalsDogsHumansMicePyrazolesRatsResearch DesignSulfur CompoundsMRI-1867PyrazolesSulfur CompoundsADMEHermansky-Pudlak syndromeIn vivo chiral conversionPBPK modelingPK scalingPulmonary Fibrosis

Identifiers

PMID37890204
PMCPMC10715448
OpenAlexW4387964795

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.